Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Di Virgilio, Ana Laura | - |
| dc.creator | Arnal, Pablo Maximiliano | - |
| dc.creator | Maisuls, Ivan | - |
| dc.date | 2017-09-21T17:09:25Z | - |
| dc.date | 2017-09-21T17:09:25Z | - |
| dc.date | 2014-06 | - |
| dc.date | 2017-09-19T14:17:06Z | - |
| dc.date.accessioned | 2019-04-29T15:35:34Z | - |
| dc.date.available | 2019-04-29T15:35:34Z | - |
| dc.date.issued | 2017-09-21T17:09:25Z | - |
| dc.date.issued | 2017-09-21T17:09:25Z | - |
| dc.date.issued | 2014-06 | - |
| dc.date.issued | 2017-09-19T14:17:06Z | - |
| dc.identifier | Di Virgilio, Ana Laura; Arnal, Pablo Maximiliano; Maisuls, Ivan; Biocompatibility of core@shell particles: Cytotoxicity and genotoxicity in human osteosarcoma cells of colloidal silica spheres coated with crystalline or amorphous zirconia; Elsevier Science; Mutation Research. Genetic Toxicology And Environmental Mutagenesis; 770; 6-2014; 85-94 | - |
| dc.identifier | 1383-5718 | - |
| dc.identifier | http://hdl.handle.net/11336/24809 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/297360 | - |
| dc.description | The cytotoxicity and genotoxicity of novel colloidal silica spheres coated with crystalline or amorphous zirconia (SiO2@ZrO2 cryst or SiO2@ZrO2 am) have been studied in a human osteosarcoma cell line (MG-63), after 24 h exposure. SiO2@ZrO2 cryst and SiO2@ZrO2 am had mean diameters of 782 ± 19 and 891 ± 34 nm, respectively. SiO2@ZrO2 cryst exposure reduced cell viability, with an increase in reactive oxygen species (ROS) and a decrease of the GSH/GSSG ratio. The comet and micronucleus (MN) assays detected DNA damage at 5 and 25 g/mL, respectively. SiO2@ZrO2 am induced genotoxic action only at 10 and 50 g/mL (comet and MN assays), along with a decrease of the GSH/GSSG ratio at 50 g/mL. Both particles were found inside the cells, forming vesicles; however, none of them entered the nucleus. Our findings show that crystallization of the shell of the amorphous ZrO2 increases both cytotoxicity and genotoxicity. | - |
| dc.description | Fil: Di Virgilio, Ana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina. Universidad Nacional de la Plata. Facultad de Cs.exactas. Departamento de Cs.biológicas. Cátedra Bioquímica Patologica; Argentina | - |
| dc.description | Fil: Arnal, Pablo Maximiliano. Provincia de Buenos Aires. Gobernación. Comision de Invest.científicas. Centro de Tecnología de Recursos Minerales y Ceramica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Tecnología de Recursos Minerales y Ceramica; Argentina | - |
| dc.description | Fil: Maisuls, Ivan. Universidad Nacional de la Plata. Facultad de Cs.exactas. Departamento de Cs.biológicas. Cátedra Bioquímica Patologica; Argentina. Provincia de Buenos Aires. Gobernación. Comision de Invest.científicas. Centro de Tecnología de Recursos Minerales y Ceramica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Tecnología de Recursos Minerales y Ceramica; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Elsevier Science | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1383571814001612 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.mrgentox.2014.05.009 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | Core@shell materials | - |
| dc.subject | Cytotoxicity | - |
| dc.subject | Genotoxicity | - |
| dc.subject | Zirconia | - |
| dc.subject | a Silica | - |
| dc.subject | Human osteosarcoma cells | - |
| dc.subject | Bioquímica y Biología Molecular | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Biocompatibility of core@shell particles: Cytotoxicity and genotoxicity in human osteosarcoma cells of colloidal silica spheres coated with crystalline or amorphous zirconia | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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