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Campo DC Valor Lengua/Idioma
dc.creatorFreitag, Nancy-
dc.creatorTirado González, Irene-
dc.creatorBarrientos, Gabriela Laura-
dc.creatorHerse, Florian-
dc.creatorThijssen, Victor L. J. L.-
dc.creatorWeedon Fekjaer, Susanne M.-
dc.creatorSchulz, Herbert-
dc.creatorWallukat, Gerd-
dc.creatorKlapp, Burghard F.-
dc.creatorNevers, Tania-
dc.creatorSharma, Surendra-
dc.creatorStaff, Anne Cathrine-
dc.creatorDechend, Ralf-
dc.creatorBlois, Sandra M.-
dc.date2017-07-26T17:22:49Z-
dc.date2017-07-26T17:22:49Z-
dc.date2013-06-
dc.date2017-07-18T15:34:34Z-
dc.date.accessioned2019-04-29T15:35:46Z-
dc.date.available2019-04-29T15:35:46Z-
dc.date.issued2017-07-26T17:22:49Z-
dc.date.issued2017-07-26T17:22:49Z-
dc.date.issued2013-06-
dc.date.issued2017-07-18T15:34:34Z-
dc.identifierFreitag, Nancy; Tirado González, Irene; Barrientos, Gabriela Laura; Herse, Florian; Thijssen, Victor L. J. L.; et al.; Interfering with Gal-1–mediated angiogenesis contributes to the pathogenesis of preeclampsia; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 110; 28; 6-2013; 11451-11456-
dc.identifier0027-8424-
dc.identifierhttp://hdl.handle.net/11336/21337-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/297409-
dc.descriptionPreeclampsia (PE) is a pregnancy-specific disorder characterized by sudden onset of hypertension and proteinuria in the second half of pregnancy (>20 wk). PE is strongly associated with abnormal placentation and an excessive maternal inflammatory response. Galectin-1 (Gal-1), a member of a family of carbohydrate-binding proteins, has been shown to modulate several processes associated with placentation and to promote maternal tolerance toward fetal antigens. Here, we show that Gal-1 exhibits proangiogenic functions during early stages of pregnancy, promoting decidual vascular expansion through VEGF receptor 2 signaling. Blocking Gal-1– mediated angiogenesis or lectin, galactoside-binding, soluble, 1 de- ficiency results in a spontaneous PE-like syndrome in mice, mainly by deregulating processes associated with good placentation and maternal spiral artery remodeling. Consistent with these findings, we observed a down-regulation of Gal-1 in patients suffering from early onset PE. Collectively, these results strengthen the notion that Gal-1 is required for healthy gestation and highlight Gal-1 as a valuable biomarker for early PE diagnosis.-
dc.descriptionFil: Freitag, Nancy. Universitätsmedizin Berlin; Alemania-
dc.descriptionFil: Tirado González, Irene. Universitätsmedizin Berlin; Alemania-
dc.descriptionFil: Barrientos, Gabriela Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Universitätsmedizin Berlin; Alemania-
dc.descriptionFil: Herse, Florian. Max-Delbrück Center for Molecular Medicine; Alemania-
dc.descriptionFil: Thijssen, Victor L. J. L.. Vrije Universiteit; Países Bajos-
dc.descriptionFil: Weedon Fekjaer, Susanne M.. University Of Oslo; Noruega-
dc.descriptionFil: Schulz, Herbert. Max-Delbrück Center for Molecular Medicine; Alemania-
dc.descriptionFil: Wallukat, Gerd. Max-Delbrück Center for Molecular Medicine; Alemania-
dc.descriptionFil: Klapp, Burghard F.. Universitätsmedizin Berlin; Alemania-
dc.descriptionFil: Nevers, Tania. University Brown; Estados Unidos-
dc.descriptionFil: Sharma, Surendra. University Brown; Estados Unidos-
dc.descriptionFil: Staff, Anne Cathrine. University Of Oslo; Noruega-
dc.descriptionFil: Dechend, Ralf. Max-Delbrück Center for Molecular Medicine; Alemania-
dc.descriptionFil: Blois, Sandra M.. Universitätsmedizin Berlin; Alemania-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherNational Academy of Sciences-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1073/pnas.1303707110-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.pnas.org/content/110/28/11451-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectGalectin-1-
dc.subjectPreeclampsia-
dc.subjectAngiogenesis-
dc.subjectInmunología-
dc.subjectMedicina Básica-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.titleInterfering with Gal-1–mediated angiogenesis contributes to the pathogenesis of preeclampsia-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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