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| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | CONICET | - |
| dc.creator | Ferreyra Solari, Nazarena Eugenia | - |
| dc.creator | Galoppo, Cristina | - |
| dc.creator | Cuarterolo, Miriam | - |
| dc.creator | Goñi, Javier | - |
| dc.creator | Fernández Salazar, Luis | - |
| dc.creator | Arranz, Luis E. | - |
| dc.creator | Garrote, Jose A. | - |
| dc.creator | Cherñavsky, Alejandra Claudia | - |
| dc.date | 2019-01-08T21:07:58Z | - |
| dc.date | 2019-01-08T21:07:58Z | - |
| dc.date | 2010-12 | - |
| dc.date | 2019-01-07T13:35:44Z | - |
| dc.date.accessioned | 2019-04-29T15:36:08Z | - |
| dc.date.available | 2019-04-29T15:36:08Z | - |
| dc.date.issued | 2010-12 | - |
| dc.identifier | Ferreyra Solari, Nazarena Eugenia; Galoppo, Cristina; Cuarterolo, Miriam; Goñi, Javier; Fernández Salazar, Luis; et al.; The simultaneous high expression of Vα24, IFN-γ and FoxP3 characterizes the liver of children with type I autoimmune hepatitis; Academic Press Inc Elsevier Science; Clinical Immunology; 137; 3; 12-2010; 396-405 | - |
| dc.identifier | 1521-6616 | - |
| dc.identifier | http://hdl.handle.net/11336/67731 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/297496 | - |
| dc.description | The immunopathogenesis of type I autoimmune hepatitis (AIH-I) might involve the deregulation of different cellular processes. Here, we investigated the liver expression of selected cytokines and genes of regulatory cell populations in children both at diagnosis and during biochemical remission following immunosuppressive treatment (AIH-Ir). We found a higher Vα24, IFN-γ, FoxP3, IL-27p28, IL-12p40 and IL-21 expression at diagnosis as well as a positive correlation between IL-21 and transaminase levels. Interestingly, only IFN-γ and FoxP3 were decreased in AIH-Ir. An "AIH-I phenotype" (high Vα24, IFN-γ and FoxP3 expression at diagnosis) was observed in only 5 out of 22 AIH-Ir patients but not in controls. These results indicate a local deregulation of the innate and adaptive immune responses with an increased transcriptional activity of immunoregulatory cells at diagnosis. In addition, IL-21 is highlighted as a mediator of liver injury. AIH-Ir is characterized by a partial reversal of the deregulated response. © 2010 Elsevier Inc. | - |
| dc.description | Fil: Ferreyra Solari, Nazarena Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina | - |
| dc.description | Fil: Galoppo, Cristina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina | - |
| dc.description | Fil: Cuarterolo, Miriam. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina | - |
| dc.description | Fil: Goñi, Javier. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina | - |
| dc.description | Fil: Fernández Salazar, Luis. Hospital Clínico Universitario de Valladolid; España | - |
| dc.description | Fil: Arranz, Luis E.. Universidad de Valladolid; España | - |
| dc.description | Fil: Garrote, Jose A.. Universidad de Valladolid; España. Hospital Clínico Universitario de Valladolid; España | - |
| dc.description | Fil: Cherñavsky, Alejandra Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Academic Press Inc Elsevier Science | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.clim.2010.08.013 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1521661610007096 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/67731 | - |
| dc.subject | REGULATORY SUBPOPULATIONS | - |
| dc.subject | TH1/TH17 CYTOKINES | - |
| dc.subject | TYPE I AUTOIMMUNE HEPATITIS | - |
| dc.subject | Salud Ocupacional | - |
| dc.subject | Ciencias de la Salud | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | The simultaneous high expression of Vα24, IFN-γ and FoxP3 characterizes the liver of children with type I autoimmune hepatitis | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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