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dc.provenanceCONICET-
dc.creatorFernández Vallone, Valeria Beatriz-
dc.creatorHofer, Erica L.-
dc.creatorChoi, Hosoon-
dc.creatorBordenave, Raúl H.-
dc.creatorBatagelj, Emilio-
dc.creatorFeldman, Leonardo-
dc.creatorLa Russa, Vincent-
dc.creatorCaramutti, Daniela-
dc.creatorDimase, Federico-
dc.creatorLabovsky, Vivian-
dc.creatorMartinez, Leandro Marcelo-
dc.creatorChasseing, Norma Alejandra-
dc.date2016-05-23T13:44:04Z-
dc.date2016-05-23T13:44:04Z-
dc.date2013-03-01-
dc.date2016-05-10T13:46:59Z-
dc.date.accessioned2019-04-29T15:36:16Z-
dc.date.available2019-04-29T15:36:16Z-
dc.date.issued2013-03-01-
dc.identifierFernández Vallone, Valeria Beatriz; Hofer, Erica L.; Choi, Hosoon; Bordenave, Raúl H.; Batagelj, Emilio; et al.; Behaviour of mesenchymal stem cells from bone marrow of untreated advanced breast and lung cancer patients before bone osteolytic metastasis; Springer; Clinical & Experimental Metastasis; 30; 3; 1-3-2013; 317-332-
dc.identifier1573-7276-
dc.identifierhttp://hdl.handle.net/11336/5777-
dc.identifier1573-7276-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/297555-
dc.descriptionTumour cells can find in bone marrow (BM) a niche rich in growth factors and cytokines that promote their self-renewal, proliferation and survival. In turn, tumour cells affect the homeostasis of the BM and bone, as well as the balance among haematopoiesis, osteogenesis, osteoclastogenesis and bone-resorption. As a result, growth and survival factors normally sequestered in the bone matrix are released, favouring tumour development. Mesenchymal stem cells (MSCs) from BM can become tumour-associated fibroblasts, have immunosuppressive function, and facilitate metastasis by epithelial-to-mesenchymal transition. Moreover, MSCs generate osteoblasts and osteocytes and regulate osteoclastogenesis. Therefore, MSCs can play an important pro-tumorigenic role in the formation of a microenvironment that promotes BM and bone metastasis. In this study we showed that BM MSCs from untreated advanced breast and lung cancer patients, without bone metastasis, had low osteogenic and adipogenic differentiation capacity compared to that of healthy volunteers. In contrast, chondrogenic differentiation was increased. Moreover, MSCs from patients had lower expression of CD146. Finally, our data showed higher levels of Dkk-1 in peripheral blood plasma from patients compared with healthy volunteers. Because no patient had any bone disorder by the time of the study we propose that the primary tumour altered the plasticity of MSCs. As over 70 % of advanced breast cancer patients and 30–40 % of lung cancer patients will develop osteolytic bone metastasis for which there is no total cure, our findings could possibly be used as predictive tools indicating the first signs of future bone disease. In addition, as the MSCs present in the BM of these patients may not be able to regenerate bone after the tumour cells invasion into BM/bone, it is possible that they promote the cycle between tumour cell growth and bone destruction.-
dc.descriptionFil: Fernández Vallone, Valeria Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina-
dc.descriptionFil: Hofer, Erica L.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina-
dc.descriptionFil: Choi, Hosoon. Texas A&M Health Science Center; Estados Unidos-
dc.descriptionFil: Bordenave, Raúl H.. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos "Dr. Isidoro G. Iriarte" Quilmes; Argentina-
dc.descriptionFil: Batagelj, Emilio. Ministerio de Defensa. Ejercito Argentino. Hospital Militar Central Cirujano Mayor "Cosme Argerich"; Argentina-
dc.descriptionFil: Feldman, Leonardo. Fundacion Favaloro; Argentina-
dc.descriptionFil: La Russa, Vincent. Memorial Sloan Kettering Cancer Center; Estados Unidos-
dc.descriptionFil: Caramutti, Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina-
dc.descriptionFil: Dimase, Federico. Ministerio de Defensa. Ejercito Argentino. Hospital Militar Central Cirujano Mayor "Cosme Argerich"; Argentina-
dc.descriptionFil: Labovsky, Vivian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina-
dc.descriptionFil: Martinez, Leandro Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina-
dc.descriptionFil: Chasseing, Norma Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina-
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dc.languageeng-
dc.publisherSpringer-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1007/s10585-012-9539-4-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s10585-012-9539-4-
dc.relationinfo:eu-repo/semantics/altIdentifier/pmid/23053744-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs10585-012-9539-4-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.source.urihttp://hdl.handle.net/11336/5777-
dc.subjectCELULAS MADRE MESENQUIMALES-
dc.subjectOSTEOGENESIS-
dc.subjectCANCER DE MAMA-
dc.subjectMETASTASIS OSEA-
dc.subjectMEDICINA REGENERATIVA-
dc.subjectBONE MARROW-
dc.subjectMedicina Química-
dc.subjectMedicina Básica-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.subjectOncología-
dc.subjectMedicina Clínica-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.titleBehaviour of mesenchymal stem cells from bone marrow of untreated advanced breast and lung cancer patients before bone osteolytic metastasis-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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