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dc.provenanceCONICET-
dc.creatorTesan, Fiorella Carla-
dc.creatorPortillo, Mariano Gastón-
dc.creatorMartinel Lamas, Diego José-
dc.creatorMedina, Vanina Araceli-
dc.creatorSalgueiro, María Jimena-
dc.creatorZubillaga, Marcela Beatriz-
dc.date2018-06-08T15:05:33Z-
dc.date2018-06-08T15:05:33Z-
dc.date2017-02-
dc.date2018-06-06T19:42:59Z-
dc.date.accessioned2019-04-29T15:36:32Z-
dc.date.available2019-04-29T15:36:32Z-
dc.date.issued2017-02-
dc.identifierTesan, Fiorella Carla; Portillo, Mariano Gastón; Martinel Lamas, Diego José; Medina, Vanina Araceli; Salgueiro, María Jimena; et al.; Hepato and Cardiotoxicity of Chemotherapeutic Treatment Evaluated by Means of Small Animal Imaging; Bentham Science Publishers; Anti-cancer Agents In Medicinal Chemistry; 17; 3; 2-2017; 359-364-
dc.identifier1871-5206-
dc.identifierhttp://hdl.handle.net/11336/47857-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/297661-
dc.descriptionBackground: Chemotherapy is one of the most common approaches for cancer treatment. Particularly Doxorubicin has been proven to be effective in the treatment of many soft and solid tumors for locally advanced and metastatic cancer. It is not easy to clinically evaluate the chemotoxic or chemoprotective effect of some drugs, even more when there is a subclinical toxicity. Objective: To determine the usefulness of the hepatobiliary, colloid and cardiac scintigraphies, employing 99mTc-disida, 99mTc-phytate and 99mTc-sestamibi respectively, in the evaluation of the hepato and cardiotoxicity of two chemotherapeutic treatments assessed in rats. Method: Two groups were submitted to doxorubicin (DOX) treatment and one was co-administered with histamine (DOX+HIS). Static 99mTc-phytate and 99mTc-sestamibi scintigraphies as well as a dynamic 99mTc-disida study were performed in a small field of view gamma camera at: 0 weeks (control), 1 week and 2 weeks of treatment. Imagenological parameters were calculated: Liver/Bone Marrow ratio (L/BM), Heart/Background ratio (H/B) and time to the maximum (Tmax) for 99mTc-phytate, 99mTc-sestamibi and 99mTc-disida extraction, respectively. Results: Control (L/BM= 98±3; H/B=2.3±0.4; Tmax=8±3), DOX (L/BM: 85±3, 80±3; H/B, 3.5±0.5, 3.3±0.5 and Tmax 6±1, 4±1) for 1 and 2 weeks respectively and DOX+HIS (L/BM: 99±0.3, 98±1; H/B 2.9±0.5, 2.9±0.5 and Tmax, 8±2, 9±2) for 1 and 2 weeks, respectively. Histological analysis showed cardio and hepatotoxicity induced by doxorubicin. Conclusion: Imagenological parameters showed differences among treated and control groups and between both chemotherapy treatments. Thus, these radiopharmaceutical functional approaches were able to reflect heart and liver toxicity produced by doxorubicin.-
dc.descriptionFil: Tesan, Fiorella Carla. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina-
dc.descriptionFil: Portillo, Mariano Gastón. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina-
dc.descriptionFil: Martinel Lamas, Diego José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina-
dc.descriptionFil: Medina, Vanina Araceli. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina-
dc.descriptionFil: Salgueiro, María Jimena. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina-
dc.descriptionFil: Zubillaga, Marcela Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherBentham Science Publishers-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.2174/1871520616666151110130619-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/136791/article-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.source.urihttp://hdl.handle.net/11336/47857-
dc.subjectCardiotoxicity-
dc.subjectDoxorubicin-
dc.subjectHepatotoxicity-
dc.subjectSmall animal imaging-
dc.subject99mTc-phytate-
dc.subject99mTc-disid-
dc.subject99mTc-sestamibi-
dc.subjectMedicina Critica y de Emergencia-
dc.subjectMedicina Clínica-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.titleHepato and Cardiotoxicity of Chemotherapeutic Treatment Evaluated by Means of Small Animal Imaging-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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