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dc.provenanceCONICET-
dc.creatorEtchegaray, Jean Pierre-
dc.creatorChavez, Lukas-
dc.creatorHuang, Yun-
dc.creatorRoss, Kenneth N.-
dc.creatorChoi, Jiho-
dc.creatorMartinez Pastor, Barbara-
dc.creatorWalsh, Ryan M.-
dc.creatorSommer, Cesar A.-
dc.creatorLienhard, Matthias-
dc.creatorGladden, Adrianne-
dc.creatorKugel, Sita-
dc.creatorSilberman, Dafne Magalí-
dc.creatorRamaswamy, Sridhar-
dc.creatorMostoslavsky, Gustavo-
dc.creatorHochedlinger, Konrad-
dc.creatorGoren, Alon-
dc.creatorRao, Anjana-
dc.creatorMostoslavsky, Raul-
dc.date2018-05-14T20:39:28Z-
dc.date2018-05-14T20:39:28Z-
dc.date2015-05-
dc.date2018-03-13T18:15:49Z-
dc.date.accessioned2019-04-29T15:36:48Z-
dc.date.available2019-04-29T15:36:48Z-
dc.date.issued2015-05-
dc.identifierEtchegaray, Jean Pierre; Chavez, Lukas; Huang, Yun; Ross, Kenneth N.; Choi, Jiho; et al.; The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine; Nature Publishing Group; Nature Cell Biology; 17; 5; 5-2015; 545-557-
dc.identifier1465-7392-
dc.identifierhttp://hdl.handle.net/11336/45155-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/297758-
dc.descriptionHow embryonic stem cells (ESCs) commit to specific cell lineages and yield all cell types of a fully formed organism remains a major question. ESC differentiation is accompanied by large-scale histone and DNA modifications, but the relations between these epigenetic categories are not understood. Here we demonstrate the interplay between the histone deacetylase sirtuin 6 (SIRT6) and the ten-eleven translocation enzymes (TETs). SIRT6 targets acetylated histone H3 at Lys 9 and 56 (H3K9ac and H3K56ac), while TETs convert 5-methylcytosine into 5-hydroxymethylcytosine (5hmC). ESCs derived from Sirt6 knockout (S6KO) mice are skewed towards neuroectoderm development. This phenotype involves derepression of OCT4, SOX2 and NANOG, which causes an upregulation of TET-dependent production of 5hmC. Genome-wide analysis revealed neural genes marked with 5hmC in S6KO ESCs, thereby implicating TET enzymes in the neuroectoderm-skewed differentiation phenotype. We demonstrate that SIRT6 functions as a chromatin regulator safeguarding the balance between pluripotency and differentiation through Tet-mediated production of 5hmC.-
dc.descriptionFil: Etchegaray, Jean Pierre. Harvard Medical School; Estados Unidos-
dc.descriptionFil: Chavez, Lukas. La Jolla Institute for Allergy and Immunology; Estados Unidos. Texas A&M University; Estados Unidos-
dc.descriptionFil: Huang, Yun. La Jolla Institute for Allergy and Immunology; Estados Unidos. Texas A&M University; Estados Unidos-
dc.descriptionFil: Ross, Kenneth N.. Harvard Medical School; Estados Unidos-
dc.descriptionFil: Choi, Jiho. Harvard Medical School; Estados Unidos-
dc.descriptionFil: Martinez Pastor, Barbara. Harvard Medical School; Estados Unidos-
dc.descriptionFil: Walsh, Ryan M.. Harvard Medical School; Estados Unidos-
dc.descriptionFil: Sommer, Cesar A.. Boston University; Estados Unidos-
dc.descriptionFil: Lienhard, Matthias. La Jolla Institute for Allergy and Immunology; Estados Unidos-
dc.descriptionFil: Gladden, Adrianne. Massachusetts Institute of Technology; Estados Unidos-
dc.descriptionFil: Kugel, Sita. Harvard Medical School; Estados Unidos-
dc.descriptionFil: Silberman, Dafne Magalí. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina-
dc.descriptionFil: Ramaswamy, Sridhar. Harvard Medical School; Estados Unidos. Boston University; Estados Unidos-
dc.descriptionFil: Mostoslavsky, Gustavo. Boston University; Estados Unidos-
dc.descriptionFil: Hochedlinger, Konrad. Harvard Medical School; Estados Unidos. Howard Hughes Medical Institute; Estados Unidos-
dc.descriptionFil: Goren, Alon. Massachusetts Institute of Technology; Estados Unidos-
dc.descriptionFil: Rao, Anjana. La Jolla Institute for Allergy and Immunology; Estados Unidos. University of California at San Diego; Estados Unidos-
dc.descriptionFil: Mostoslavsky, Raul. Harvard Medical School; Estados Unidos-
dc.formatapplication/pdf-
dc.formatapplication/vnd.openxmlformats-officedocument.wordprocessingml.document-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherNature Publishing Group-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/ncb3147-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/ncb3147-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593707/-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttps://creativecommons.org/licenses/by/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.source.urihttp://hdl.handle.net/11336/45155-
dc.subjectSITR6-
dc.subjectSTEM CELLS-
dc.subjectDEVELOPMENT-
dc.subjectOtras Ciencias Biológicas-
dc.subjectCiencias Biológicas-
dc.subjectCIENCIAS NATURALES Y EXACTAS-
dc.titleThe histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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