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dc.provenanceCONICET-
dc.creatorMuscia, Gisela Celeste-
dc.creatorBuldain, Graciela Yolanda-
dc.creatorAsís, Silvia Elizabeth-
dc.date2017-12-11T18:55:39Z-
dc.date2017-12-11T18:55:39Z-
dc.date2013-12-
dc.date2017-12-11T16:46:10Z-
dc.date.accessioned2019-04-29T15:36:51Z-
dc.date.available2019-04-29T15:36:51Z-
dc.date.issued2013-12-
dc.identifierMuscia, Gisela Celeste; Buldain, Graciela Yolanda; Asís, Silvia Elizabeth; Synthesis and evaluation of acridine and fused-quinoline derivatives as potential anti-tuberculosis agents; Elsevier Masson; European Journal of Medical Chemistry; 73; 12-2013; 243-249-
dc.identifier0223-5234-
dc.identifierhttp://hdl.handle.net/11336/30181-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/297768-
dc.descriptionThe synthesis of twelve acridine and polycyclic acridine derivatives prepared via the Friedländer reaction is described. The one-pot reactions of 2-amino-5-chloro or 5-nitro-benzophenones and a variety of cyclanones and indanones were carried out in a MW oven under TFA catalysis in good yields. The products were designed according natural antituberculosis products and were evaluated for growth inhibitory activity towards Mycobacterium tuberculosis H37Rv (Mtb) through the National Institute of Allergy and Infectious Diseases (NIAID, USA). Three of them underwent additional testings. The cyclopenta[b]quinoline derivative 9 and the acridine derivative 13 showed remarkable MIC values against the rifampin resistant strain. The former exhibited bactericidal activity at 50 μg/mL, its intracellular activity is similar to rifampin and it was not cytotoxic at low concentrations so it can be considered a new lead compound.-
dc.descriptionFil: Muscia, Gisela Celeste. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina-
dc.descriptionFil: Buldain, Graciela Yolanda. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina-
dc.descriptionFil: Asís, Silvia Elizabeth. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica; Argentina-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherElsevier Masson-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0223523413008003-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.ejmech.2013.12.013-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.source.urihttp://hdl.handle.net/11336/30181-
dc.subjectMYCOBACTERIUM TUBERCULOSIS-
dc.subjectACRIDINAS-
dc.subjectFRIEDLÄNDER-
dc.subjectINHIBIDOR-
dc.subjectOtras Ciencias Químicas-
dc.subjectCiencias Químicas-
dc.subjectCIENCIAS NATURALES Y EXACTAS-
dc.titleSynthesis and evaluation of acridine and fused-quinoline derivatives as potential anti-tuberculosis agents-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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