Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | CONICET | - |
| dc.creator | Baudou, Federico Gastón | - |
| dc.creator | Litwin, Silvana | - |
| dc.creator | Lanari, Laura Cecilia | - |
| dc.creator | Laskowicz, Rodrigo Daniel | - |
| dc.creator | Damin, Carlos Fabian | - |
| dc.creator | Chippaux, Jean-Philippe | - |
| dc.creator | de Roodt, Adolfo Rafael | - |
| dc.date | 2019-03-20T17:54:27Z | - |
| dc.date | 2019-03-20T17:54:27Z | - |
| dc.date | 2017-12 | - |
| dc.date | 2019-03-20T13:29:19Z | - |
| dc.date.accessioned | 2019-04-29T15:36:56Z | - |
| dc.date.available | 2019-04-29T15:36:56Z | - |
| dc.date.issued | 2017-12 | - |
| dc.identifier | Baudou, Federico Gastón; Litwin, Silvana; Lanari, Laura Cecilia; Laskowicz, Rodrigo Daniel; Damin, Carlos Fabian; et al.; Antivenom against Crotalus durissus terrificus venom: Immunochemical reactivity and experimental neutralizing capacity; Pergamon-Elsevier Science Ltd; Toxicon; 140; 12-2017; 11-17 | - |
| dc.identifier | 0041-0101 | - |
| dc.identifier | http://hdl.handle.net/11336/72109 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/297788 | - |
| dc.description | The venom of Crotalus durissus terrificus produces a neurotoxic and myotoxic syndrome that can lead to the death. Specific antivenom is the only treatment to neutralize the toxicity of the venom and the precocity in applying the antivenom is crucial for the efficiency of the treatment. We studied the variation of the immunochemical reactivity and neutralizing capacity of the specific antivenom on this venom in pre-incubation and rescue experiments, at different times. ELISA titers increased with longer venom-antivenom incubation times (p < 0.05) nevertheless incubation times had no effect on the neutralizing capacity of the antivenom. The antivenom dose necessary to rescue mice injected with 1.5 MMD (minimal mortal dose) 30 min after venom inoculation was over ten folds the dose of antivenom theoretically required to neutralize the same dose of venom according values obtained from pre-incubation experiments. Results showed that the in vitro immunochemical reactivity is not directly related to the neutralizing capacity. These observations underline the need for a rapid antivenom administration. Although preincubation experiments in mice are a powerful tool for the validation of the potency of the antivenoms in the productive process, it is clear that the nominal neutralization of the antivenoms must not be considered as a “stoichiometric” value regarding the venom to be neutralized in case of natural envenomation and emphasize the need of realization of clinical trials in order to evaluate the adequate doses of antivenom to be therapeutically used. | - |
| dc.description | Fil: Baudou, Federico Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina | - |
| dc.description | Fil: Litwin, Silvana. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina | - |
| dc.description | Fil: Lanari, Laura Cecilia. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina | - |
| dc.description | Fil: Laskowicz, Rodrigo Daniel. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina | - |
| dc.description | Fil: Damin, Carlos Fabian. Universidad de Buenos Aires. Facultad de Medicina; Argentina | - |
| dc.description | Fil: Chippaux, Jean-Philippe. Universite de Paris I Pantheon - Sorbonne; Francia | - |
| dc.description | Fil: de Roodt, Adolfo Rafael. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Pergamon-Elsevier Science Ltd | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.toxicon.2017.10.009 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0041010117303069 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/72109 | - |
| dc.subject | ANTIVENOM | - |
| dc.subject | CROTALUS DURISSUS TERRIFICUS | - |
| dc.subject | DOSAGE | - |
| dc.subject | INCUBATION | - |
| dc.subject | NEUTRALIZATION | - |
| dc.subject | RESCUE | - |
| dc.subject | TREATMENT | - |
| dc.subject | VENOM | - |
| dc.subject | Otras Ciencias Biológicas | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Antivenom against Crotalus durissus terrificus venom: Immunochemical reactivity and experimental neutralizing capacity | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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