Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | CONICET | - |
| dc.creator | May, Maria | - |
| dc.creator | Mosto, Julian | - |
| dc.creator | Martinez Vazquez, Paula | - |
| dc.creator | Gonzalez, Pedro | - |
| dc.creator | Rojas, Paola Andrea | - |
| dc.creator | Gass, Hugo | - |
| dc.creator | Lanari, Claudia Lee Malvina | - |
| dc.creator | Molinolo, Alfredo A. | - |
| dc.date | 2016-12-05T15:20:31Z | - |
| dc.date | 2016-12-05T15:20:31Z | - |
| dc.date | 2016-02 | - |
| dc.date | 2016-10-04T19:26:54Z | - |
| dc.date.accessioned | 2019-04-29T15:37:02Z | - |
| dc.date.available | 2019-04-29T15:37:02Z | - |
| dc.date.issued | 2016-02 | - |
| dc.identifier | May, Maria; Mosto, Julian; Martinez Vazquez, Paula; Gonzalez, Pedro; Rojas, Paola Andrea; et al.; Nuclear staining of fgfr-2/stat-5 and runx-2 in mucinous breast cancer; Elsevier; Experimental And Molecular Pathology; 100; 1; 2-2016; 39-44 | - |
| dc.identifier | 0014-4800 | - |
| dc.identifier | http://hdl.handle.net/11336/8768 | - |
| dc.identifier | 1096-0945 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/297812 | - |
| dc.description | Mucinous carcinoma (MBC) is a rare subtype of breast cancer characterized by the production of variable amounts of mucin, with a prognosis better than that of non-mucinous carcinomas (NMBC). The aim of this project was to evaluate the expression of STAT-5, RUNX-2, and FGFR-2 in a cohort of MBC and compare it with that of NMBC using standard immunohistochemistry. STAT-5 and RUNX-2 are two transcription factors with cytoplasmic and/or nuclear localization that have been related to FGFR-2, a tyrosine kinase growth factor receptor that can interact with STAT-5 and with PR in the nuclei of breast cancer cells. Membranous, cytoplasmic, and nuclear staining were evaluated and expressed as the percentage of stained cells (0-100%) multiplied by the staining intensity (0-3), thus obtaining an index ranging from 0 to 300. Nuclear and/or cytoplasmic immunoreactivity of the three proteins were detected in a high number of NMBC. Nuclear FGFR-2 staining correlated with nuclear STAT-5 (p<0.05) and nuclear RUNX-2 (p<0.01) in both tumor types; however MBC had a significant higher expression of nuclear FGFR-2 (p<0.01) and RUNX-2 (p<0.05) than that of NMBC, and displayed positive immunoreactivity of the 3 proteins in 70.8% of the cases. These results suggest that these proteins may have a role in the progression of the mucinous phenotype, in which nuclear STAT-5 may inhibit RUNX-2 prometastatic effect. | - |
| dc.description | Fil: May, Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina | - |
| dc.description | Fil: Mosto, Julian. | - |
| dc.description | Fil: Martinez Vazquez, Paula. Hospital General de Pacheco; Argentina. Ministerio de Salud Provincia de Buenos Aires. Hospital Zonal Gral. de Agudos "Magdalena Villegas de Martinez"; Argentina | - |
| dc.description | Fil: Gonzalez, Pedro. Ministerio de Salud Provincia de Buenos Aires. Hospital Zonal Gral. de Agudos "Magdalena Villegas de Martinez"; Argentina | - |
| dc.description | Fil: Rojas, Paola Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina | - |
| dc.description | Fil: Gass, Hugo. Ministerio de Salud Provincia de Buenos Aires. Hospital Zonal Gral. de Agudos "Magdalena Villegas de Martinez"; Argentina | - |
| dc.description | Fil: Lanari, Claudia Lee Malvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina | - |
| dc.description | Fil: Molinolo, Alfredo A.. University Of California At San Diego; Estados Unidos | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Elsevier | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0014480015002142 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1016/j.yexmp.2015.11.003 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/8768 | - |
| dc.subject | BREAST | - |
| dc.subject | STAT5 | - |
| dc.subject | RUNX2 | - |
| dc.subject | FGFR2 | - |
| dc.subject | ADENOCARCINOMA | - |
| dc.subject | Patología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.subject | Anatomía y Morfología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Nuclear staining of fgfr-2/stat-5 and runx-2 in mucinous breast cancer | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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