Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | CONICET | - |
| dc.creator | Hofer, Erica Leonor | - |
| dc.creator | La Russa, Vincent | - |
| dc.creator | Honegger, Alba Elizabeth | - |
| dc.creator | Bullorsky, Eduardo Oscar | - |
| dc.creator | Bordenave, Raúl Horacio | - |
| dc.creator | Chasseing, Norma Alejandra | - |
| dc.date | 2018-01-26T17:57:10Z | - |
| dc.date | 2018-01-26T17:57:10Z | - |
| dc.date | 2005-12 | - |
| dc.date | 2017-12-28T13:40:05Z | - |
| dc.date.accessioned | 2019-04-29T15:37:36Z | - |
| dc.date.available | 2019-04-29T15:37:36Z | - |
| dc.date.issued | 2005-12 | - |
| dc.identifier | Hofer, Erica Leonor; La Russa, Vincent; Honegger, Alba Elizabeth; Bullorsky, Eduardo Oscar; Bordenave, Raúl Horacio; et al.; Alteration on the expression of IL-1, PDGF, TGF-beta, EGF, and FGF receptors and c-Fos and c-Myc proteins in bone marrow mesenchymal stroma cells from advanced untreated lung and breast cancer patients.; Mary Ann Liebert, Inc Publishers.; Stem Cells and Development; 14; 5; 12-2005; 587-594 | - |
| dc.identifier | 1547-3287 | - |
| dc.identifier | http://hdl.handle.net/11336/34701 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/298016 | - |
| dc.description | Previously, we reported a deficient cloning capacity of the bone marrow (BM) mesenchymal stem cells to give colony-forming unit fibroblast (CFU-F) and an inefficient confluence capacity of BM stromal cells in advanced untreated lung cancer patients (LCP) and breast cancer patients (BCP). Moreover, a decreased level of bFGF at day 7 in the conditioned media from BM CFU-F cultures was found in both cancer groups when compared to the normal range. The current study was specially undertaken, to evaluate the percentage of subconfluent fibroblasts expressing receptors (R) of interleukin-1 (IL-1), platelet-derived growth factor (PDGF), fibroblast growth factor (FGF), transforming growth factor (TGF-alfa), epidermal growth factor (EGF), and the proteins c-Fos and c-Myc in BM primary cultures from untreated LCP and BCP. An immunocytochemical study on subconfluent BM fibroblast cultures from 13 healthy patients, 16 LCP, and 8 BCP was performed, using as primary antibodies, anti-type I of IL-1 R (IL-1R-1), anti-á, â chains of PDGF R (PDGFR-alfa, PDGFR-beta), anti-type I of FGF R (FGFR-I), anti-type I, II, and III of TGF-alfa R (TGF-alfa R-I, TGF- alfa R-II, and TGF-alfa R-III), anti-EGF R, anti-c-Fos, and anti-c-Myc. A diminished percentage of subconfluent fibroblasts expressing PDGFR-alfa, TGF alfa R-I, II, III, EGFR, and FGFR-I was found in LCP and BCP compared to healthy patients. A diminished percentage of subconfluent fibroblasts expressing c-Fos and c-Myc was found in patients when compared to healthy patients. The alterations we describe could help to explain the deficiency regarding the proliferative and confluence capacity of BM stroma cells in cancer patients. | - |
| dc.description | Fil: Hofer, Erica Leonor. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina | - |
| dc.description | Fil: La Russa, Vincent. Memorial Sloan Kettering Cancer Center; Reino Unido | - |
| dc.description | Fil: Honegger, Alba Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina | - |
| dc.description | Fil: Bullorsky, Eduardo Oscar. Hospital Británico de Buenos Aires; Argentina | - |
| dc.description | Fil: Bordenave, Raúl Horacio. Hospital de Agudos Dr. Iriarte; Argentina | - |
| dc.description | Fil: Chasseing, Norma Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | spa | - |
| dc.publisher | Mary Ann Liebert, Inc Publishers. | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://online.liebertpub.com/doi/pdfplus/10.1089/scd.2005.14.587 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1089/scd.2005.14.587 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/34701 | - |
| dc.subject | células madre mesenquimales | - |
| dc.subject | Cáncer de mama | - |
| dc.subject | Cáncer de pulmón | - |
| dc.subject | factores de crecimiento | - |
| dc.subject | Medicina Critica y de Emergencia | - |
| dc.subject | Medicina Clínica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Alteration on the expression of IL-1, PDGF, TGF-beta, EGF, and FGF receptors and c-Fos and c-Myc proteins in bone marrow mesenchymal stroma cells from advanced untreated lung and breast cancer patients. | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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