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dc.provenanceCONICET-
dc.creatorPagano, Eleonora-
dc.creatorFontana, Vanina Andrea-
dc.creatorCalvo, Juan Carlos-
dc.date2016-12-28T17:00:11Z-
dc.date2016-12-28T17:00:11Z-
dc.date2011-09-
dc.date2016-12-27T20:13:06Z-
dc.date.accessioned2019-04-29T15:38:22Z-
dc.date.available2019-04-29T15:38:22Z-
dc.date.issued2011-09-
dc.identifierPagano, Eleonora; Fontana, Vanina Andrea; Calvo, Juan Carlos; Expression of erythroblastic leukemia viral oncogene homolog (erbBS) mRNAs and possible splice variants in 3T3-L1 preadipocytes; Spandidos Publ Ltd; Molecular Medicine Reports; 4; 5; 9-2011; 955-961-
dc.identifier1791-2997-
dc.identifierhttp://hdl.handle.net/11336/10474-
dc.identifier1791-3004-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/298255-
dc.descriptionPreviously, we studied the erythroblastic leukemia viral oncogene homolog (erbB) family of tyrosine kinase growth factor receptors in terms of protein expression, modulation and activation in the 3T3-L1 cell line. In the present study, the presence of full-length erbB mRNAs, and splice or proteolytic erbB variants, was evaluated using RT-PCR. Epidermal growth factor receptor (EGFR)/erbB1 expression was confirmed. Wild-type (wt) ErbB2, human erbB2 (HER2)-extracellular domain (ECD) and herstatin mRNA expression were analyzed. Restriction analysis confirmed wt expression. 3T3-L1 cells exhibited HER2-ECD and herstatin mRNA expression, although at extremely low levels (compared to the control cell lines). ErbB3 cDNA was amplified using mouse mammary tumors and rat acines as positive controls. ErbB4 was not positively identified in these cells. In conclusion, this study demonstrates that 3T3-L1 cells express EGFR/erbB1, erbB2 and erbB3, and possibly, certain erbB2 splice or proteolytic variants, which are worth pursuing.-
dc.descriptionFil: Pagano, Eleonora. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Pontificia Universidad Católica Argentina "Santa María de Los Buenos Aires"; Argentina-
dc.descriptionFil: Fontana, Vanina Andrea. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina-
dc.descriptionFil: Calvo, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherSpandidos Publ Ltd-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.spandidos-publications.com/10.3892/mmr.2011.517-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3892/mmr.2011.517-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.source.urihttp://hdl.handle.net/11336/10474-
dc.subjectERYTHROBLASTIC LEUKEMIA VIRAL ONCOGENE HOMOLOG-
dc.subjectEPIDERMAL GROWTH FACTOR RECEPTOR-
dc.subject3T3-L1 CELLS-
dc.subjectPREADIPOCYTES-
dc.subjectBioquímica y Biología Molecular-
dc.subjectCiencias Biológicas-
dc.subjectCIENCIAS NATURALES Y EXACTAS-
dc.titleExpression of erythroblastic leukemia viral oncogene homolog (erbBS) mRNAs and possible splice variants in 3T3-L1 preadipocytes-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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