Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | CONICET | - |
| dc.creator | Cottliar, Alejandra | - |
| dc.creator | Fundia, Ariela Freya | - |
| dc.creator | Boerr, Luis | - |
| dc.creator | Sambuelli, Alicia | - |
| dc.creator | Negreira, Silvia | - |
| dc.creator | Gil, Anibal | - |
| dc.creator | Gomez, Juan Carlos | - |
| dc.creator | Chopita, Nestor | - |
| dc.creator | Bernedo, Alberto | - |
| dc.creator | Slavutsky, Irma Rosa | - |
| dc.date | 2018-08-13T18:56:37Z | - |
| dc.date | 2018-08-13T18:56:37Z | - |
| dc.date | 2000-09 | - |
| dc.date | 2018-08-08T14:48:19Z | - |
| dc.date.accessioned | 2019-04-29T15:38:23Z | - |
| dc.date.available | 2019-04-29T15:38:23Z | - |
| dc.date.issued | 2000-09 | - |
| dc.identifier | Cottliar, Alejandra; Fundia, Ariela Freya; Boerr, Luis; Sambuelli, Alicia; Negreira, Silvia; et al.; High frequencies of telomeric associations, chromosome aberrations, and sister chromatid exchanges in ulcerative colitis; Nature Publishing Group; American Journal Of Gastroenterology; 95; 9; 9-2000; 2301-2307 | - |
| dc.identifier | 0002-9270 | - |
| dc.identifier | http://hdl.handle.net/11336/55192 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/298262 | - |
| dc.description | Chromosome instability provides a predisposing background to malignancy, contributing to the crucial genetic changes in multistep carcinogenesis. The aim of this work was to analyze chromosome instability in patients with ulcerative colitis (UC) to achieve a better understanding of the increased risk for colorectal cancer. METHODS: Peripheral blood lymphocyte cultures from 20 untreated UC patients and 24 controls were used to study chromosome instability by assessing telomeric associations (TAS), chromosome aberrations (CA), and sister chromatid exchanges (SCE). RESULTS: Mean frequencies of TAS and CA were significantly increased in UC patients compared to controls (p < 0.001). Chromosomes 10, 11, 21, 16, and 19 were the most frequently involved in TAS. A total of 104 CA clustered in 66 breakpoints could be exactly localized. Seven nonrandom bands significantly affected in UC patients were found (p < 0.004), showing a significant correlation with the location of cancer breakpoints (p < 0.003), particularly with colorectal carcinoma rearrangements. SCE analysis showed higher levels in patients compared to controls (p < 0.006), but no differences were observed in cell cycle kinetics. CONCLUSIONS: Our results demonstrate the presence of an unstable genome in UC patients that could be related to the cancer development observed in this disease. | - |
| dc.description | Fil: Cottliar, Alejandra. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina | - |
| dc.description | Fil: Fundia, Ariela Freya. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina | - |
| dc.description | Fil: Boerr, Luis. Hospital de Gastroenterología “Bonorino Udaondo,; Argentina | - |
| dc.description | Fil: Sambuelli, Alicia. Hospital de Gastroenterología “Bonorino Udaondo,; Argentina | - |
| dc.description | Fil: Negreira, Silvia. Hospital de Gastroenterología “Bonorino Udaondo,; Argentina | - |
| dc.description | Fil: Gil, Anibal. Hospital de Gastroenterología “Bonorino Udaondo,; Argentina | - |
| dc.description | Fil: Gomez, Juan Carlos. Provincia de Buenos Aires. Hospital Interzonal General de Agudos Gral. San Martin; Argentina | - |
| dc.description | Fil: Chopita, Nestor. Provincia de Buenos Aires. Hospital Interzonal General de Agudos Gral. San Martin; Argentina | - |
| dc.description | Fil: Bernedo, Alberto. Provincia de Buenos Aires. Hospital Interzonal General de Agudos Gral. San Martin; Argentina | - |
| dc.description | Fil: Slavutsky, Irma Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Nature Publishing Group | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1111/j.1572-0241.2000.02315.x | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/ajg2000581 | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/55192 | - |
| dc.subject | ULCERATIVE COLITIS | - |
| dc.subject | CHROMOSOME ABERRATIONS | - |
| dc.subject | TELOMERIC ASSOCIATIONS | - |
| dc.subject | SISTER CHROMATID EXCHANGE | - |
| dc.subject | Inmunología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | High frequencies of telomeric associations, chromosome aberrations, and sister chromatid exchanges in ulcerative colitis | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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