Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | CONICET | - |
| dc.creator | Gismondi, Maria Ines | - |
| dc.creator | Díaz Carrasco, Juan María | - |
| dc.creator | Valva, Pamela | - |
| dc.creator | Becker, Pablo Daniel | - |
| dc.creator | Guzman, Carlos Alberto | - |
| dc.creator | Campos, Rodolfo Hector | - |
| dc.creator | Preciado, Maria Victoria | - |
| dc.date | 2017-05-02T19:25:40Z | - |
| dc.date | 2017-05-02T19:25:40Z | - |
| dc.date | 2013-12 | - |
| dc.date | 2017-04-28T17:11:23Z | - |
| dc.date.accessioned | 2019-04-29T15:38:26Z | - |
| dc.date.available | 2019-04-29T15:38:26Z | - |
| dc.date.issued | 2013-12 | - |
| dc.identifier | Gismondi, Maria Ines; Díaz Carrasco, Juan María; Valva, Pamela; Becker, Pablo Daniel; Guzman, Carlos Alberto; et al.; Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children; Elsevier Inc; Virology; 447; 1-2; 12-2013; 187-196 | - |
| dc.identifier | 0042-6822 | - |
| dc.identifier | http://hdl.handle.net/11336/15891 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/298279 | - |
| dc.description | Classic phylogenetic and modern population-based clustering methods were used to analyze hepatitis C virus (HCV) evolution in plasma and to assess viral compartmentalization within peripheral blood mononuclear cells (PBMCs) in 6 children during 3.2–9.6 yr of follow-up. Population structure analysis of cloned amplicons encompassing hypervariable region 1 led to the distinction of two evolutionary patterns, one highly divergent and another one genetically homogeneous. Viral adaptability was reflected by co-evolution of viral communities switching rapidly from one to another in the context of divergence and stability associated with highly homogeneous communities which were replaced by new ones after long periods. Additionally, viral compartmentalization of HCV in PBMCs was statistically demonstrated, suggesting their role as a pool of genetic variability. Our results support the idea of a community-based structure of HCV viral populations during chronic infection and highlight a role of the PBMC compartment in the persistence of such structure. | - |
| dc.description | Fil: Gismondi, Maria Ines. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Díaz Carrasco, Juan María. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Valva, Pamela. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Becker, Pablo Daniel. Helmholtz Centre For Infection Research; Alemania | - |
| dc.description | Fil: Guzman, Carlos Alberto. Helmholtz Centre For Infection Research; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Campos, Rodolfo Hector. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Preciado, Maria Victoria. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Elsevier Inc | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0042682213005114 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.virol.2013.09.002 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/15891 | - |
| dc.subject | COMPARTMENTALIZATION | - |
| dc.subject | EVOLUTION | - |
| dc.subject | HEPATITIS C VIRUS | - |
| dc.subject | PBMC | - |
| dc.subject | PEDIATRIC INFECTION | - |
| dc.subject | POPULATION STRUCTURE | - |
| dc.subject | Enfermedades Infecciosas | - |
| dc.subject | Ciencias de la Salud | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.subject | Virología | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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