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| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | CONICET | - |
| dc.creator | Giambelluca, Miriam Soledad | - |
| dc.creator | Gende, Oscar Alfredo | - |
| dc.date | 2018-09-26T15:29:39Z | - |
| dc.date | 2018-09-26T15:29:39Z | - |
| dc.date | 2011 | - |
| dc.date | 2018-09-10T16:43:12Z | - |
| dc.date.accessioned | 2019-04-29T15:38:34Z | - |
| dc.date.available | 2019-04-29T15:38:34Z | - |
| dc.date.issued | 2011 | - |
| dc.identifier | Giambelluca, Miriam Soledad; Gende, Oscar Alfredo; Cl-/HCO3- exchange activity in fMLP-stimulated human neutrophils; Academic Press Inc Elsevier Science; Biochemical and Biophysical Research Communications; 409; 3; 2011; 567-571 | - |
| dc.identifier | 0006-291X | - |
| dc.identifier | http://hdl.handle.net/11336/60871 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/298342 | - |
| dc.description | It is well known that chemotactic agents active Na+/H+ exchanger, increasing intracellular pH of neutrophils, but their effect on bicarbonate transporters have not been established yet. To study the effect of fMLP on the activity of Cl/HCO3 exchange, the rate of pH recovery after acute Cl readmission in cell subjected to an alkaline load by CO2 washout in a Cl-free medium was measured. The activity of the exchanger was reduced to 72% of control when cells were pre-incubated for 5 min with 0.1 lM fMLP and reached 48% of control in steady state after acute exposure. After extracellular bicarbonate or TMA addition the rate recovery of intracellular pH was reduce at 72% and at 84%, respectively. The inhibitory effect on the intracellular pH recovery was not affected by blockers of Na+/H+ xchange. We conclude from these studies that an increase of pHi produced for this chemotactic agent is facilitated by the simultaneous activation of Na+/H+ exchange and inhibition of Cl/HCO 3 exchange in neutrophils. | - |
| dc.description | Fil: Giambelluca, Miriam Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Cardiovasculares ; Argentina | - |
| dc.description | Fil: Gende, Oscar Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Cardiovasculares ; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Academic Press Inc Elsevier Science | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0006291X11008060 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.bbrc.2011.05.046 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/60871 | - |
| dc.subject | CHLORIDE-BICARBONATE EXCHANGER | - |
| dc.subject | NEUTROPHILS | - |
| dc.subject | INTRACELULAR PH | - |
| dc.subject | CHLORIDE | - |
| dc.subject | Bioquímica y Biología Molecular | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Cl-/HCO3- exchange activity in fMLP-stimulated human neutrophils | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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