Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | CONICET | - |
| dc.creator | Simula, Silvina | - |
| dc.creator | Ozuna, Paola Villán | - |
| dc.creator | Otero, Javier | - |
| dc.creator | Casas, José | - |
| dc.creator | Sanjuan, Norberto Aníbal | - |
| dc.date | 2019-01-03T17:26:39Z | - |
| dc.date | 2019-01-03T17:26:39Z | - |
| dc.date | 2012-05 | - |
| dc.date | 2019-01-02T19:50:03Z | - |
| dc.date.accessioned | 2019-04-29T15:38:36Z | - |
| dc.date.available | 2019-04-29T15:38:36Z | - |
| dc.date.issued | 2012-05 | - |
| dc.identifier | Simula, Silvina; Ozuna, Paola Villán; Otero, Javier; Casas, José; Sanjuan, Norberto Aníbal; Polyomavirus-induced pilomatricomas in mice: From viral inoculation to tumour development; Wiley Blackwell Publishing, Inc; Apmis; 120; 5; 5-2012; 397-404 | - |
| dc.identifier | 0903-4641 | - |
| dc.identifier | http://hdl.handle.net/11336/67299 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/298362 | - |
| dc.description | Polyomavirus has been used extensively to study tumour induction in mice. Although most neoplasms are well characterized, those arising from hair follicles have been referred to by different names during the last four decades. The purpose of this research was to contribute to a more accurate histological characterization of these tumours as well as to study the viral progression from the onset of infection to the development of neoplasms. Polyomavirus A2 was inoculated into newborn C3H/BiDa mice, and at different time-points (from 5 to 70days post-inoculation) the mice were sacrificed and studied using histological, immunocytochemical, ultrastructural and virological methods. The fully developed hair follicle tumours consisted of a proliferation of matrix cells that evolved into 'shadow' cells with empty nuclei and finally into amorphous keratin; the tumours were therefore diagnosed as pilomatricomas. Viral VP-1 was observed only in fully differentiated cells and not in proliferating-cell-nuclear-antigen (PCNA)-positive cells in the same tumour. In conclusion, Polyomavirus first replicated in the skin, and then disseminated through the blood and reached the outer sheath of the hair follicles and finally infected matrix cells, leading to the development of pilomatricomas from which infectious virus was isolated. © 2011 The Authors. APMIS © 2011 APMIS. | - |
| dc.description | Fil: Simula, Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina | - |
| dc.description | Fil: Ozuna, Paola Villán. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina | - |
| dc.description | Fil: Otero, Javier. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Patología; Argentina | - |
| dc.description | Fil: Casas, José. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina | - |
| dc.description | Fil: Sanjuan, Norberto Aníbal. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Wiley Blackwell Publishing, Inc | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1111/j.1600-0463.2011.02839.x | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0463.2011.02839.x | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/67299 | - |
| dc.subject | HAIR FOLLICLE | - |
| dc.subject | ONCOGENESIS | - |
| dc.subject | PILOMATRICOMA | - |
| dc.subject | POLYOMA | - |
| dc.subject | Inmunología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Polyomavirus-induced pilomatricomas in mice: From viral inoculation to tumour development | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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