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dc.provenanceCONICET-
dc.creatorSavtchouk, Iaroslav-
dc.creatorSun, Lu-
dc.creatorBender, Crhistian Luis-
dc.creatorLee, Hyang Burm-
dc.creatorSzabó, Gábor-
dc.creatorGasparini, Sonia-
dc.creatorLiu, Siqiong June-
dc.date2018-06-28T15:11:25Z-
dc.date2018-06-28T15:11:25Z-
dc.date2016-09-
dc.date2018-06-26T17:18:07Z-
dc.date.accessioned2019-04-29T15:38:47Z-
dc.date.available2019-04-29T15:38:47Z-
dc.date.issued2016-09-
dc.identifierSavtchouk, Iaroslav; Sun, Lu; Bender, Crhistian Luis; Lee, Hyang Burm; Szabó, Gábor; et al.; Topological regulation of synaptic AMPA receptor expression by the RNA-Binding protein CPEB3; Elsevier B.V.; Cell Reports; 17; 1; 9-2016; 86-103-
dc.identifier2211-1247-
dc.identifierhttp://hdl.handle.net/11336/50350-
dc.identifier2211-1247-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/298443-
dc.descriptionSynaptic receptors gate the neuronal response to incoming signals, but they are not homogeneously distributed on dendrites. A spatially defined receptor distribution can preferentially amplify certain synaptic inputs, resize receptive fields of neurons, and optimize information processing within a neuronal circuit. Thus, a longstanding question is how the spatial organization of synaptic receptors is achieved. Here, we find that action potentials provide local signals that influence the distribution of synaptic AMPA receptors along dendrites in mouse cerebellar stellate cells. Graded dendritic depolarizations elevate CPEB3 protein at proximal dendrites, where we suggest that CPEB3 binds to GluA2 mRNA, suppressing GluA2 protein synthesis leading to a distance-dependent increase in synaptic GluA2 AMPARs. The activity-induced expression of CPEB3 requires increased Ca2+ and PKC activation. Our results suggest a cell-autonomous mechanism where sustained postsynaptic firing drives graded local protein synthesis, thus directing the spatial organization of synaptic AMPARs.-
dc.descriptionFil: Savtchouk, Iaroslav. University of Pennsylvania; Estados Unidos. LSU Health Sciences Center. Department of Cell Biology and Anatomy; Estados Unidos-
dc.descriptionFil: Sun, Lu. LSU Health Sciences Center. Department of Cell Biology and Anatomy; Estados Unidos. University of Pennsylvania; Estados Unidos-
dc.descriptionFil: Bender, Crhistian Luis. LSU Health Sciences Center. Department of Cell Biology and Anatomy; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina-
dc.descriptionFil: Lee, Hyang Burm. LSU Health Sciences Center. Department of Cell Biology and Anatomy; Estados Unidos. University of Pennsylvania; Estados Unidos-
dc.descriptionFil: Szabó, Gábor. Institute Of Experimental Medicine Hungarian Academy Of Sciences; . LSU Health Sciences Center. Department of Cell Biology and Anatomy; Estados Unidos. Institute of Experimental Medicine. Laboratory of Molecular Biology and Genetics; Hungría-
dc.descriptionFil: Gasparini, Sonia. LSU Health Sciences Center. Neuroscience Center of Excellence; Estados Unidos. LSU Health Sciences Center. Department of Cell Biology and Anatomy; Estados Unidos-
dc.descriptionFil: Liu, Siqiong June. LSU Health Sciences Center. Department of Cell Biology and Anatomy; Estados Unidos. University of Pennsylvania; Estados Unidos-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherElsevier B.V.-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.celrep.2016.08.094-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2211124716312037-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.source.urihttp://hdl.handle.net/11336/50350-
dc.subjectACTION POTENTIALS-
dc.subjectAMPA RECEPTOR-
dc.subjectCALCIUM IMAGING-
dc.subjectCEREBELLAR STELLATE CELL-
dc.subjectCPEB3-
dc.subjectDENDRITIC GRADIENT-
dc.subjectGLUA2-
dc.subjectPKC-
dc.subjectSUBUNIT COMPOSITION-
dc.subjectTOPOSTATIC PLASTICITY-
dc.subjectInmunología-
dc.subjectMedicina Básica-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.titleTopological regulation of synaptic AMPA receptor expression by the RNA-Binding protein CPEB3-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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