Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | CONICET | - |
| dc.creator | Bonnet, Gemma | - |
| dc.creator | Gómez Abellán, Purificación | - |
| dc.creator | Vera, Beatriz | - |
| dc.creator | Sánchez Romera, Juan Francisco | - |
| dc.creator | Hernández Martínez, Antonio M. | - |
| dc.creator | Sookoian, Silvia Cristina | - |
| dc.creator | Pirola, Carlos José | - |
| dc.creator | Garaulet, Marta | - |
| dc.date | 2018-06-05T13:28:51Z | - |
| dc.date | 2018-06-05T13:28:51Z | - |
| dc.date | 2017-11 | - |
| dc.date | 2018-06-04T17:11:22Z | - |
| dc.date.accessioned | 2019-04-29T15:39:04Z | - |
| dc.date.available | 2019-04-29T15:39:04Z | - |
| dc.date.issued | 2017-11 | - |
| dc.identifier | Bonnet, Gemma; Gómez Abellán, Purificación; Vera, Beatriz; Sánchez Romera, Juan Francisco; Hernández Martínez, Antonio M.; et al.; Serotonin-transporter promoter polymorphism modulates the ability to control food intake: Effect on total weight loss; Wiley VCH Verlag; Molecular Nutrition & Food Research; 61; 11; 11-2017; 1-37 | - |
| dc.identifier | 1613-4125 | - |
| dc.identifier | http://hdl.handle.net/11336/47279 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/298566 | - |
| dc.description | SCOPE:The biggest challenge for losing weight is the ability to control the amount of food eaten; the tendency to overeat is called disinhibition. Our aims were to determine whether a) the SLC6A4-promoter variant (5-HTTLPR) relates to disinhibition; b) this association could affect total weight-loss during a behavioral/dietary treatment for obesity.METHODS AND RESULTS:2961 subjects attended voluntarily five weight-loss clinics; a subsample (n = 624) was recruited for SLC6A4 genotyping. Total weight-loss, Emotional-Eating-Score and Disinhibition-Score were examined. We observed that: a) the reduced ability to control food intake (disinhibition) is implicated in the impairment to lose weight; b) SLC6A4-promoter variant is implicated in disinhibition. S carriers (low-expressing) of the SLC6A4-promoter variant had a lower inhibition capacity and showed more failure (1.6 times) to control the amount of food eaten than LL (P<0.05); other factors such as eating while bored, overeating after work at night, or craving for specific foods were associated to the SLC6A4 genotype (P<0.05); c) The combination of disinhibition (high disinhibition) and genetics (S carrier) had a higher impact on total weight loss than each factor separately.CONCLUSIONS:SLC6A4-promoter variant is associated with the ability to control food intake and interacts with emotional eating to modulate total weight loss | - |
| dc.description | Fil: Bonnet, Gemma. Universidad de Murcia; España | - |
| dc.description | Fil: Gómez Abellán, Purificación. Universidad de Murcia; España | - |
| dc.description | Fil: Vera, Beatriz. Universidad de Murcia; España | - |
| dc.description | Fil: Sánchez Romera, Juan Francisco. Universidad de Murcia; España | - |
| dc.description | Fil: Hernández Martínez, Antonio M.. Universidad de Murcia; España | - |
| dc.description | Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina | - |
| dc.description | Fil: Pirola, Carlos José. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina | - |
| dc.description | Fil: Garaulet, Marta. Universidad de Murcia; España | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Wiley VCH Verlag | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1002/mnfr.201700494 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.201700494 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/47279 | - |
| dc.subject | SEROTONIN TRANSPORTER | - |
| dc.subject | SLC6A4 | - |
| dc.subject | OBESITY | - |
| dc.subject | WEIGHT LOSS | - |
| dc.subject | Medicina Critica y de Emergencia | - |
| dc.subject | Medicina Clínica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.subject | Inmunología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Serotonin-transporter promoter polymorphism modulates the ability to control food intake: Effect on total weight loss | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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