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| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | CONICET | - |
| dc.creator | Hasenahuer, Marcia Anahí | - |
| dc.creator | Parisi, Gustavo Daniel | - |
| dc.creator | Gautier, Marien | - |
| dc.creator | Lazarowski, Alberto Jorge | - |
| dc.creator | Bramuglia, Guillermo Federico | - |
| dc.creator | Fornasari, Maria Silvina | - |
| dc.date | 2018-04-20T17:02:29Z | - |
| dc.date | 2018-04-20T17:02:29Z | - |
| dc.date | 2015-11 | - |
| dc.date | 2018-04-17T13:58:14Z | - |
| dc.date.accessioned | 2019-04-29T15:39:17Z | - |
| dc.date.available | 2019-04-29T15:39:17Z | - |
| dc.date.issued | 2015-11 | - |
| dc.identifier | Hasenahuer, Marcia Anahí; Parisi, Gustavo Daniel; Gautier, Marien; Lazarowski, Alberto Jorge; Bramuglia, Guillermo Federico; et al.; Twenty‐One Novel EGFR Kinase Domain variants in Patients with Nonsmall Cell Lung Cancer; Wiley Blackwell Publishing, Inc; Annals Of Human Genetics; 79; 11-2015; 385-393 | - |
| dc.identifier | 0003-4800 | - |
| dc.identifier | http://hdl.handle.net/11336/42837 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/298665 | - |
| dc.description | Somatic sequence variants in the epidermal growth factor receptor (EGFR) kinase domain are associated with sensitivity to tyrosine kinase inhibitors (TKIs) in patients with nonsmall cell lung cancer (NSCLC). Patients exhibiting sequence variants in this domain that produce kinase activity enhancement, are more likely to benefit from TKIs than patients with EGFR wild-type disease. Although most NSCLC EGFR-related alleles are concentrated in a few positions, established protocols recommend sequencing EGFR exons 18?21. In this study, 21 novel somatic variants belonging to such exons in adult Argentinean patients affected with NSCLC are reported. Of these, 18 were single amino acid substitutions (SASs), occurring alone or in combination with another genetic alteration (complex cases), one was a short deletion, one was a short deletion-short insertion combination, and one was a duplication. New variants and different combinations of previously reported variants were also found. Moreover, two of the reported SASs occurred in previously unreported positions of the EGFR kinase domain. In order to characterize the new sequence variants, physicochemical, sequence and conformational analyses were also performed. A better understanding of sequence variants in NSCLC may facilitate the most appropriate treatment choice for this complex disease. | - |
| dc.description | Fil: Hasenahuer, Marcia Anahí. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina | - |
| dc.description | Fil: Parisi, Gustavo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina | - |
| dc.description | Fil: Gautier, Marien. Fundación Investigar; Argentina | - |
| dc.description | Fil: Lazarowski, Alberto Jorge. Fundación Investigar; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina | - |
| dc.description | Fil: Bramuglia, Guillermo Federico. Fundación Investigar; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina | - |
| dc.description | Fil: Fornasari, Maria Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Wiley Blackwell Publishing, Inc | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/ahg.12127 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/ahg.12127 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/42837 | - |
| dc.subject | PROTEIN | - |
| dc.subject | VARIATIONS | - |
| dc.subject | HUMAN | - |
| dc.subject | DISEASE | - |
| dc.subject | Otras Ciencias Biológicas | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.subject | Ciencias de la Computación | - |
| dc.subject | Ciencias de la Computación e Información | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.subject | Salud Ocupacional | - |
| dc.subject | Ciencias de la Salud | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Twenty‐One Novel EGFR Kinase Domain variants in Patients with Nonsmall Cell Lung Cancer | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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