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dc.provenanceCONICET-
dc.creatorGarcía Cordero, Indira Ruth-
dc.creatorSedeño, Lucas-
dc.creatorFraiman Borrazás, Daniel Edmundo-
dc.creatorCraiem, Damian-
dc.creatorde la Fuente de la Torre, Laura Alethia-
dc.creatorSalamone, Paula Celeste-
dc.creatorSerrano, Cecilia Mariela-
dc.creatorSposato, Luciano A.-
dc.creatorManes, Facundo Francisco-
dc.creatorIbáñez Barassi, Agustín Mariano-
dc.date2019-02-04T16:31:45Z-
dc.date2019-02-04T16:31:45Z-
dc.date2015-09-
dc.date2019-02-04T13:12:31Z-
dc.date.accessioned2019-04-29T15:39:25Z-
dc.date.available2019-04-29T15:39:25Z-
dc.date.issued2015-09-
dc.identifierGarcía Cordero, Indira Ruth; Sedeño, Lucas; Fraiman Borrazás, Daniel Edmundo; Craiem, Damian; de la Fuente de la Torre, Laura Alethia; et al.; Stroke and Neurodegeneration Induce Different Connectivity Aberrations in the Insula; Lippincott Williams; Stroke; 46; 9; 9-2015; 2673-2677-
dc.identifier0039-2499-
dc.identifierhttp://hdl.handle.net/11336/69288-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/298726-
dc.descriptionBackground and Purpose - Stroke and neurodegeneration cause significant brain damage and cognitive impairment, especially if the insular cortex is compromised. This study explores for the first time whether these 2 causes differentially alter connectivity patterns in the insular cortex. Methods - Resting state-functional magnetic resonance imaging data were collected from patients with insular stroke, patients with behavioral variant frontotemporal dementia, and healthy controls. Data from the 3 groups were assessed through a correlation function analysis. Specifically, we compared decreases in connectivity as a function of voxel Euclidean distance within the insular cortex. Results - Relative to controls, patients with stroke showed faster connectivity decays as a function of distance (hypoconnectivity). In contrast, the behavioral variant frontotemporal dementia group exhibited significant hyperconnectivity between neighboring voxels. Both patient groups evinced global hypoconnectivity. No between-group differences were observed in a volumetrically and functionally comparable region without ischemia or neurodegeneration. Conclusions - Functional insular cortex connectivity is affected differently by cerebral ischemia and neurodegeneration, possibly because of differences in the cause-specific pathophysiological mechanisms of each disease. These findings have important clinical and theoretical implications.-
dc.descriptionFil: García Cordero, Indira Ruth. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Sedeño, Lucas. Instituto de Neurología Cognitiva; Argentina. Universidad Diego Portales; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Fraiman Borrazás, Daniel Edmundo. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Craiem, Damian. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: de la Fuente de la Torre, Laura Alethia. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Salamone, Paula Celeste. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Serrano, Cecilia Mariela. Memory and Balance Clinic; Argentina-
dc.descriptionFil: Sposato, Luciano A.. Western University; Canadá-
dc.descriptionFil: Manes, Facundo Francisco. Instituto de Neurología Cognitiva; Argentina. Universidad Diego Portales; Chile. ARC Centre of Excellence in Cognition and its Disorders; Australia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Ibáñez Barassi, Agustín Mariano. Instituto de Neurología Cognitiva; Argentina. Universidad Diego Portales; Chile. Universidad Autónoma del Caribe; Colombia. ARC Centre of Excellence in Cognition and its Disorders; Australia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
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dc.languageeng-
dc.publisherLippincott Williams-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1161/STROKEAHA.115.009598-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.ahajournals.org/doi/10.1161/STROKEAHA.115.009598-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.source.urihttp://hdl.handle.net/11336/69288-
dc.subjectCEREBRAL CORTEX-
dc.subjectDEMENTIA-
dc.subjectMAGNETIC RESONANCE IMAGING-
dc.subjectSTROKE-
dc.subjectNeurología Clínica-
dc.subjectMedicina Clínica-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.titleStroke and Neurodegeneration Induce Different Connectivity Aberrations in the Insula-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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