Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | CONICET | - |
| dc.creator | Davies, Carolina | - |
| dc.creator | Day, Nilay | - |
| dc.creator | Sánchez Negrette, Olga | - |
| dc.creator | Parada, Luis Antonio | - |
| dc.creator | Basombrio, Miguel Angel Manuel | - |
| dc.creator | Garg, Nisha Jain | - |
| dc.date | 2016-08-11T14:31:25Z | - |
| dc.date | 2016-08-11T14:31:25Z | - |
| dc.date | 2014-10-16 | - |
| dc.date | 2016-08-04T18:17:38Z | - |
| dc.date.accessioned | 2019-04-29T15:39:34Z | - |
| dc.date.available | 2019-04-29T15:39:34Z | - |
| dc.date.issued | 2014-10-16 | - |
| dc.identifier | Davies, Carolina; Day, Nilay ; Sánchez Negrette, Olga ; Parada, Luis Antonio; Basombrio, Miguel Angel Manuel; et al.; Hepatotoxicity in mice of a novel anti-parasite drug candidate hydroxymethylnitrofurazone: a comparison with Benznidazole; Public Library Of Science; Neglected Tropical Diseases; 8; 10; 16-10-2014; 1-12 | - |
| dc.identifier | 1935-2735 | - |
| dc.identifier | http://hdl.handle.net/11336/7088 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/298787 | - |
| dc.description | Hydroxymethylnitrofurazone (NFOH) is a promising drug candidate with demonstrated trypanocidal activity in experimental models ofTrypanosoma cruziinfection and chronic disease development. In this study, we monitored the safety of NFOH in established in vitro and in vivo models. Our data show that NFOH did not induce hepatocyte cell death. Short-term or long-term treatment of mice with NFOH did not induce hepatic stress measured by cellular injury, inflammation or fibrosis. Benznidazole, the currently used treatment against acute infection in humans, was more toxic and induced chronic inflammation and liver injury in mice. We conclude that NFOH should be studied further to determine its potential safety for human use as an anti-parasite therapy. | - |
| dc.description | Fil: Davies, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Patología Experimental; Argentina. Universidad Nacional de Salta; Argentina | - |
| dc.description | Fil: Day, Nilay . University Of Texas Medical Branch. Department Of Pathology; Estados Unidos | - |
| dc.description | Fil: Sánchez Negrette, Olga . Universidad Nacional de Salta. Facultad de Ciencias Exactas; Argentina | - |
| dc.description | Fil: Parada, Luis Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Patología Experimental; Argentina. Universidad Nacional de Salta; Argentina | - |
| dc.description | Fil: Basombrio, Miguel Angel Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Patología Experimental; Argentina. Universidad Nacional de Salta; Argentina | - |
| dc.description | Fil: Garg, Nisha Jain. University Of Texas Medical Branch. Department Of Pathology; Estados Unidos | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Public Library Of Science | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pntd.0003231 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371/journal.pntd.0003231 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/pmid/25329323 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pubmed/25329323 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0003231 | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/7088 | - |
| dc.subject | CHAGAS | - |
| dc.subject | TRYPANOSOMA CRUZI | - |
| dc.subject | DRUG LIVER TOXICITY | - |
| dc.subject | BENZNIDAZOLE | - |
| dc.subject | NFOH | - |
| dc.subject | Parasitología | - |
| dc.subject | Ciencias de la Salud | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Hepatotoxicity in mice of a novel anti-parasite drug candidate hydroxymethylnitrofurazone: a comparison with Benznidazole | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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