Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | CONICET | - |
| dc.creator | Piotrkowski, Barbara | - |
| dc.creator | Calabró López, María Valeria | - |
| dc.creator | Galleano, Mónica Liliana | - |
| dc.creator | Fraga, César Guillermo | - |
| dc.date | 2017-12-15T16:29:16Z | - |
| dc.date | 2017-12-15T16:29:16Z | - |
| dc.date | 2014-10 | - |
| dc.date | 2017-12-15T14:53:02Z | - |
| dc.date.accessioned | 2019-04-29T15:39:35Z | - |
| dc.date.available | 2019-04-29T15:39:35Z | - |
| dc.date.issued | 2014-10 | - |
| dc.identifier | Fraga, César Guillermo; Galleano, Mónica Liliana; Calabró López, María Valeria; Piotrkowski, Barbara; (−)-Epicatechin prevents alterations in the metabolism of superoxide anion and nitric oxide in the hearts of L-NAME-treated rats; Royal Society of Chemistry; Food and Function; 6; 10-2014; 154-160 | - |
| dc.identifier | 2042-6496 | - |
| dc.identifier | http://hdl.handle.net/11336/30756 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/298796 | - |
| dc.description | The aim of this work was to evaluate the effects of (−)-epicatechin administration in the heart of a rat model with reduced NO production that follows a short-term treatment with L-NAME. Sprague-Dawley rats were treated for 4 d with L-NAME in the absence or presence of (−)-epicatechin in the diet. The redox status in cardiac tissue was improved by (−)-epicatechin administration. L-NAME treatment induced a decrease in NO synthase activity (−62%, p < 0.05) and an increase in NADPH-dependent superoxide anion production (+300%, p < 0.05) that were totally prevented by (−)-epicatechin administration. These effects of (−)-epicatechin were associated with a higher endothelial NO synthase phosphorylation at an activation site and a reduced expression of the regulatory subunit, p47phox, suggesting the involvement of posttranslational mechanisms in (−)-epicatechin action. Thus, the (−)-epicatechin treatment would restore NO steady state levels in vivo through effects on both, its synthesis and degradation via the reaction with superoxide anion. The fact that (−)-epicatechin is commonly present in human diet makes this compound a reasonable explanation for the positive cardiovascular effects of a high consumption of fruits and vegetables. | - |
| dc.description | Fil: Piotrkowski, Barbara. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina | - |
| dc.description | Fil: Calabró López, María Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina | - |
| dc.description | Fil: Galleano, Mónica Liliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina | - |
| dc.description | Fil: Fraga, César Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Royal Society of Chemistry | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1039/c4fo00554f | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/-/content/articlehtml/2015/fo/c4fo00554f | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/30756 | - |
| dc.subject | FLAVONOIDES | - |
| dc.subject | ANION SUPEROXIDO | - |
| dc.subject | HIPERTENSION | - |
| dc.subject | Otras Ciencias Biológicas | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | (−)-Epicatechin prevents alterations in the metabolism of superoxide anion and nitric oxide in the hearts of L-NAME-treated rats | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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