Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Cebrián, José Ignacio | - |
| dc.creator | Croce, Cristina Celeste | - |
| dc.creator | Guerrero, Néstor A. | - |
| dc.creator | Blanchard, Nicolas | - |
| dc.creator | Mayorga, Luis Segundo | - |
| dc.date | 2018-06-15T22:03:59Z | - |
| dc.date | 2018-06-15T22:03:59Z | - |
| dc.date | 2016-12 | - |
| dc.date | 2018-06-13T16:52:09Z | - |
| dc.date.accessioned | 2019-04-29T15:39:40Z | - |
| dc.date.available | 2019-04-29T15:39:40Z | - |
| dc.date.issued | 2016-12 | - |
| dc.identifier | Cebrián, José Ignacio; Croce, Cristina Celeste; Guerrero, Néstor A.; Blanchard, Nicolas; Mayorga, Luis Segundo; Rab22a controls MHC-I intracellular trafficking and antigen cross-presentation by dendritic cells; Nature Publishing Group; Embo Reports; 17; 12; 12-2016; 1753-1765 | - |
| dc.identifier | 1469-221X | - |
| dc.identifier | http://hdl.handle.net/11336/48920 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/298840 | - |
| dc.description | Cross-presentation by MHC class I molecules allows the detection of exogenous antigens by CD8+ T lymphocytes. This process is crucial to initiate cytotoxic immune responses against many pathogens (i.e. Toxoplasma gondii) and tumors. To achieve efficient cross-presentation, dendritic cells (DCs) have specialized endocytic pathways; however the molecular effectors involved are poorly understood. In this work, we identify the small GTPase Rab22a as a key regulator of MHC-I trafficking and antigen cross-presentation by DCs. Our results demonstrate that Rab22a is recruited to DC endosomes and phagosomes, as well as to the vacuole containing T. gondii parasites. The silencing of Rab22a expression did not affect the uptake of exogenous antigens or parasite invasion, but it drastically reduced the intracellular pool and the recycling of MHC-I molecules. The knock-down of Rab22a also hampered the cross-presentation of soluble, particulate and T. gondii-associated antigens, but not the endogenous MHC-I antigen presentation through the classical secretory pathway. Our findings provide compelling evidence that Rab22a plays a central role in the MHC-I endocytic trafficking, which is crucial for efficient cross-presentation by DCs. | - |
| dc.description | Fil: Cebrián, José Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina | - |
| dc.description | Fil: Croce, Cristina Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina | - |
| dc.description | Fil: Guerrero, Néstor A.. Centre de Physiopathologie de Toulouse; Francia | - |
| dc.description | Fil: Blanchard, Nicolas. Centre de Physiopathologie de Toulouse; Francia | - |
| dc.description | Fil: Mayorga, Luis Segundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Nature Publishing Group | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.15252/embr.201642358 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://embor.embopress.org/content/17/12/1753 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/34770 | - |
| dc.subject | CROSS-PRESENTATION | - |
| dc.subject | DENDRITIC CELLS | - |
| dc.subject | MHC-I MOLECULES | - |
| dc.subject | SMALL GTPASE RAB22A | - |
| dc.subject | TOXOPLASMA GONDII | - |
| dc.subject | Otras Ciencias Biológicas | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.subject | Inmunología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.subject | Otras Ciencias Biológicas | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Rab22a controls MHC-I intracellular trafficking and antigen cross-presentation by dendritic cells | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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