Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Parigi, Giacomo | - |
| dc.creator | Rezaei Ghaleh, Nasrollah | - |
| dc.creator | Giachetti, Andrea | - |
| dc.creator | Becker, Stefan | - |
| dc.creator | Fernandez, Claudio Oscar | - |
| dc.creator | Blackledger, Martin | - |
| dc.creator | Griesinger, Christian | - |
| dc.creator | Zweckstetter, Markus | - |
| dc.creator | Luchinat, Claudio | - |
| dc.date | 2017-12-05T15:10:59Z | - |
| dc.date | 2017-12-05T15:10:59Z | - |
| dc.date | 2014-10 | - |
| dc.date | 2017-12-04T19:16:18Z | - |
| dc.date.accessioned | 2019-04-29T15:39:43Z | - |
| dc.date.available | 2019-04-29T15:39:43Z | - |
| dc.date.issued | 2014-10 | - |
| dc.identifier | Parigi, Giacomo; Rezaei Ghaleh, Nasrollah; Giachetti, Andrea; Becker, Stefan; Fernandez, Claudio Oscar; et al.; Long-Range Correlated Dynamics in Intrinsically Disordered Proteins; American Chemical Society; Journal of the American Chemical Society; 136; 10-2014; 16201-16209 | - |
| dc.identifier | 0002-7863 | - |
| dc.identifier | http://hdl.handle.net/11336/29703 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/298861 | - |
| dc.description | Intrinsically disordered proteins (IDPs) are involved in a wide variety of physiological and pathological processes and are best described by ensembles of rapidly interconverting conformers. Using fast field cycling relaxation measurements we here show that the IDP α-synuclein as well as a variety of other IDPs undergoes slow reorientations at time scales comparable to folded proteins. The slow motions are not perturbed by mutations in α-synuclein, which are related to genetic forms of Parkinson’s disease, and do not depend on secondary and tertiary structural propensities. Ensemble-based hydrodynamic calculations suggest that the time scale of the underlying correlated motion is largely determined by hydrodynamic coupling between locally rigid segments. Our study indicates that long-range correlated dynamics are an intrinsic property of IDPs and offers a general physical mechanism of correlated motions in highly flexible biomolecular systems | - |
| dc.description | Fil: Parigi, Giacomo. University of Florence; Italia | - |
| dc.description | Fil: Rezaei Ghaleh, Nasrollah. German Center for Neurodegenerative Diseases; Alemania. Max Planck Institute for Biophysical Chemistry; Alemania | - |
| dc.description | Fil: Giachetti, Andrea. University of Florence; Italia | - |
| dc.description | Fil: Becker, Stefan. Max Planck Institute for Biophysical Chemistry; Alemania | - |
| dc.description | Fil: Fernandez, Claudio Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Investigaciones Para El Descubrimiento de Farmacos de Rosario. Universidad Nacional de Rosario. Instituto de Investigaciones Para El Descubrimiento de Farmacos de Rosario; Argentina | - |
| dc.description | Fil: Blackledger, Martin. Institut de Biologie Structurale; Francia | - |
| dc.description | Fil: Griesinger, Christian. Max Planck Institute for Biophysical Chemistry; Alemania | - |
| dc.description | Fil: Zweckstetter, Markus. German Center for Neurodegenerative Diseases; Alemania. Max Planck Institute for Biophysical Chemistry; Alemania. University Medical Center; Alemania | - |
| dc.description | Fil: Luchinat, Claudio. University of Florence; Italia | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | American Chemical Society | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1021/ja506820r | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/10.1021/ja506820r | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/46278 | - |
| dc.subject | proteinas intrinsicamente desordenadas | - |
| dc.subject | dinamica | - |
| dc.subject | Otras Ciencias Químicas | - |
| dc.subject | Ciencias Químicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Long-Range Correlated Dynamics in Intrinsically Disordered Proteins | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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