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dc.creatorCatalano, Paolo Nicolás-
dc.creatorBonaventura, Maria Marta-
dc.creatorSilveyra, Patricia-
dc.creatorBettler, Bernhard-
dc.creatorLibertun, Carlos-
dc.creatorLux, Victoria Adela R.-
dc.date2017-12-22T05:27:03Z-
dc.date2017-12-22T05:27:03Z-
dc.date2005-12-
dc.date2017-12-19T18:36:46Z-
dc.date.accessioned2019-04-29T15:39:47Z-
dc.date.available2019-04-29T15:39:47Z-
dc.date.issued2005-12-
dc.identifierLux, Victoria Adela R.; Libertun, Carlos; Bettler, Bernhard; Silveyra, Patricia; Bonaventura, Maria Marta; Catalano, Paolo Nicolás; et al.; GABAB1 knock-out mice reveals alteration in prolactin levels, gonadotropin axis and reproductive function; Karger; Neuroendocrinology; 82; 5-6; 12-2005; 294-305-
dc.identifier0028-3835-
dc.identifierhttp://hdl.handle.net/11336/31344-
dc.identifier1423-0194-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/298885-
dc.descriptiongamma-Aminobutyric acid (GABA) has been implicated in the control of hypophyseal functions. We evaluated whether the constitutive loss of functional GABA(B) receptors in GABA(B1) knockout (GABA(B1)(-/-)) mice alters hormonal levels, under basal and stimulated conditions, and reproductive function. The serum hormone levels were measured by radioimmunoassay, the estrous cyclicity was evaluated by vaginal lavages, and the mating behavior was determined by the presence of vaginal plugs. A moderate hyperprolactinemic condition was observed, in which prolactin increase and thyroid-stimulating hormone decrease were similar between genotypes. Basal luteinizing hormone (LH), follicle-stimulating hormone, thyroid-stimulating hormone, and growth hormone levels were similar between genotypes in each sex. Analysis of the gonadotropin axis revealed no differences in puberty onset between female genotypes. In con trast, the estrous cyclicity was significantly disrupted in GABA(B1)(-/-) female mice, showing significantly extended periods in estrus and shortened periods in proestrus. Reproduction was significantly compromised in GABA(B1)(-/-) females, with a significantly lower proportion of mice (37.5%) getting pregnant during the first 30 days of mating as compared with wild-type controls (87.5%). Moreover, only 14% of vaginal plug positive GABA(B1)(-/-) females had successful pregnancies as compared with 75% in the controls. In addition, the postovariectomy LH rise was significantly advanced in GABA(B1)(-/-) mice, while the response to estradiol feedback was similar in both genotypes. In conclusion, our endocrine analysis of GABA(B1)(-/-) mice reveals that GABA(B) receptors are involved in the regulation of basal prolactin titers. Moreover, the hypothalamic-hypophyseal-ovarian axis is seriously disturbed, with alterations in cyclicity, postcastration LH increase, and fertility indexes. The molecular mechanism underlying these hormonal disturbances remains to be addressed.-
dc.descriptionFil: Catalano, Paolo Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina-
dc.descriptionFil: Bonaventura, Maria Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina-
dc.descriptionFil: Silveyra, Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina-
dc.descriptionFil: Bettler, Bernhard. University of Basel; Suiza-
dc.descriptionFil: Libertun, Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina-
dc.descriptionFil: Lux, Victoria Adela R.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina-
dc.formatapplication/pdf-
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dc.languageeng-
dc.publisherKarger-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/Abstract/93128-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1159/000093128-
dc.relationinfo:eu-repo/semantics/altIdentifier/pmid/https://www.ncbi.nlm.nih.gov/pubmed/16682806-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectESTRADIOL-
dc.subjectGROWTH HORMONE-
dc.subjectPITUITARY GLAND-
dc.subjectTESTIS-
dc.subjectREPRODUCTION PHYSIOLOGY-
dc.subjectNeurociencias-
dc.subjectMedicina Básica-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.subjectBiología Reproductiva-
dc.subjectCiencias Biológicas-
dc.subjectCIENCIAS NATURALES Y EXACTAS-
dc.titleGABAB1 knock-out mice reveals alteration in prolactin levels, gonadotropin axis and reproductive function-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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