Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Morande, Pablo Elías | - |
| dc.creator | Borge, Mercedes | - |
| dc.creator | Abreu, Cecilia | - |
| dc.creator | Galletti, Jeremías Gastón | - |
| dc.creator | Zanetti, Samanta Romina | - |
| dc.creator | Nannini, Paula Romina | - |
| dc.creator | Bezares, Fernando Raimundo | - |
| dc.creator | Pantano, Sergio | - |
| dc.creator | Dighiero, Guillermo | - |
| dc.creator | Oppezzo, Pablo | - |
| dc.creator | Gamberale, Romina | - |
| dc.creator | Giordano, Mirta Nilda | - |
| dc.date | 2016-10-26T21:25:07Z | - |
| dc.date | 2016-10-26T21:25:07Z | - |
| dc.date | 2015-01 | - |
| dc.date | 2016-02-22T14:08:13Z | - |
| dc.date.accessioned | 2019-04-29T15:39:51Z | - |
| dc.date.available | 2019-04-29T15:39:51Z | - |
| dc.date.issued | 2015-01 | - |
| dc.identifier | Morande, Pablo Elías; Borge, Mercedes; Abreu, Cecilia; Galletti, Jeremías Gastón; Zanetti, Samanta Romina; et al.; Surface localization of high-mobility group nucleosome-binding protein 2 (HMGN2) on leukemic B cells from chronic lymphocytic leukemia patients is related to secondary autoimmune hemolytic anemi; Taylor & Francis; Leukemia And Lymphoma; 56; 4; 1-2015; 1-8 | - |
| dc.identifier | 1042-8194 | - |
| dc.identifier | http://hdl.handle.net/11336/7811 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/298917 | - |
| dc.description | Chronic lymphocytic leukemia (CLL) is the main cause of autoimmune hemolytic anemia (AHA). However, the cellular basis underlying this strong association remains unclear. We previously demonstrated that leukemic B cells from patients with CLL recognize the erythrocyte protein Band 3, a prevalent autoantigen in AHA. Here we show that the major binding site of Band 3 on leukemic cells is an extrinsic protein identified as high-mobility group nucleosome binding protein 2 (HMGN2), a nucleosome-interacting factor which has not been previously reported at the cell surface. T lymphocytes do not express HMGN2 or bind Band 3. Removal of HMGN2 from the cell membrane abrogated the capacity of Band 3-pulsed CLL cells to induce CD4 + T cell proliferation. We conclude that surface HMGN2 in leukemic B cells is involved in Band 3 binding, uptake and presentation to CD4 + T lymphocytes, and as such may favor the initiation of AHA secondary to CLL. | - |
| dc.description | Fil: Morande, Pablo Elías. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; Argentina. Instituto Pasteur de Montevideo; Uruguay | - |
| dc.description | Fil: Borge, Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; Argentina | - |
| dc.description | Fil: Abreu, Cecilia. Instituto Pasteur de Montevideo. Unidad de Biologia Molecular; Uruguay | - |
| dc.description | Fil: Galletti, Jeremías Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; Argentina | - |
| dc.description | Fil: Zanetti, Samanta Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; Argentina | - |
| dc.description | Fil: Nannini, Paula Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; Argentina | - |
| dc.description | Fil: Bezares, Fernando Raimundo. Hospital Teodoro Alvarez; Argentina | - |
| dc.description | Fil: Pantano, Sergio. Instituto Pasteur de Montevideo; Uruguay | - |
| dc.description | Fil: Dighiero, Guillermo. Hospital Maciel; Uruguay | - |
| dc.description | Fil: Oppezzo, Pablo. Instituto Pasteur de Montevideo. Unidad de Biologia Molecular; Uruguay | - |
| dc.description | Fil: Gamberale, Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; Argentina | - |
| dc.description | Fil: Giordano, Mirta Nilda. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Taylor & Francis | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/full/10.3109/10428194.2014.957205 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3109/10428194.2014.957205 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/3925 | - |
| dc.subject | AUTOIMMUNE HEMOLYTIC ANEMIA | - |
| dc.subject | CHRONIC LYMPHOCYTIC LEUKEMIA | - |
| dc.subject | HMGN2 | - |
| dc.subject | Inmunología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Surface localization of high-mobility group nucleosome-binding protein 2 (HMGN2) on leukemic B cells from chronic lymphocytic leukemia patients is related to secondary autoimmune hemolytic anemi | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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