Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Joo Turoni, Claudio Martín | - |
| dc.creator | Marañón, Rodrigo Oscar | - |
| dc.creator | Karbiner, María Sofía | - |
| dc.creator | Muntaner Juan | - |
| dc.creator | Proto, Victor | - |
| dc.creator | Peral, Maria de Los Angeles | - |
| dc.date | 2018-10-22T21:55:30Z | - |
| dc.date | 2018-10-22T21:55:30Z | - |
| dc.date | 2011-08 | - |
| dc.date | 2018-10-17T15:04:32Z | - |
| dc.date.accessioned | 2019-04-29T15:40:11Z | - |
| dc.date.available | 2019-04-29T15:40:11Z | - |
| dc.date.issued | 2018-10-22T21:55:30Z | - |
| dc.date.issued | 2018-10-22T21:55:30Z | - |
| dc.date.issued | 2011-08 | - |
| dc.date.issued | 2018-10-17T15:04:32Z | - |
| dc.identifier | Joo Turoni, Claudio Martín; Marañón, Rodrigo Oscar; Karbiner, María Sofía; Muntaner Juan; Proto, Victor; et al.; Oxidative stress in hypertensive patients induces an increased contractility in vein grafts independent of endothelial function; Hindawi Publishing Corporation; International Journal of Hypertension; 2001; 8-2011; 1-8 | - |
| dc.identifier | 2090-0392 | - |
| dc.identifier | http://hdl.handle.net/11336/62907 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/299051 | - |
| dc.description | Objective. To evaluate the impact of oxidative stress on vascular reactivity to vasoconstrictors and on nitric oxide (NO) bioavailability in saphenous vein (SV) graft with endothelial dysfunction from hypertensive patients (HT). Methods. Endothelial function, vascular reactivity, oxidative state, nitrites and NO release were studied in isolated SV rings from HT and normotensive patients (NT). Only rings with endothelial dysfunction were used. Results. HT rings presented a hyperreactivity to vasoconstrictors that was reverted by diphenylene iodonium (DPI). In NT, no effect of DPI was obtained, but Nω-nitro - L - arginine methyl ester (L-NAME) increased the contractile response. NO was present in SV rings without endothelial function. Nitrites were higher in NT than in HT (1066.1 ± 86.3 pmol/mg; n = 11 versus 487.8 ± 51.6; n = 23; P 0.01) and inhibited by nNOS inhibitor. L-arginine reversed this effect. Antioxidant agents increased nitrites and NO contents only in HT. The anti-nNOS-stained area by immunohistochemistry was higher in NT than HT. HT showed an elevation of oxidative state. Conclusions. Extraendothelial NO counter-regulates contractility in SV. However, this action could be altered in hypertensive situations by an increased oxidative stress or a decreased ability of nNOS to produce NO. Further studies should be performed to evaluate the implication of these results in graft patency rates. | - |
| dc.description | Fil: Joo Turoni, Claudio Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina | - |
| dc.description | Fil: Marañón, Rodrigo Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina | - |
| dc.description | Fil: Karbiner, María Sofía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina | - |
| dc.description | Fil: Muntaner Juan. Centro Modelo de Cardiología S.r.l.; Argentina | - |
| dc.description | Fil: Proto, Victor. Centro Modelo de Cardiología S.r.l.; Argentina | - |
| dc.description | Fil: Peral, Maria de Los Angeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Hindawi Publishing Corporation | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/ijhy/2011/902129/ | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4061/2011/902129 | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | saphenous veins; oxidative stress | - |
| dc.subject | endothelial dysfunction | - |
| dc.subject | nitric oxide | - |
| dc.subject | hypertension | - |
| dc.subject | Inmunología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Oxidative stress in hypertensive patients induces an increased contractility in vein grafts independent of endothelial function | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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