Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Lozano, Esteban Sebastián | - |
| dc.creator | Strauss, Mariana | - |
| dc.creator | Spina Zapata, Renata María | - |
| dc.creator | Cifuente, Diego Alberto | - |
| dc.creator | Tonn, Carlos Eugenio | - |
| dc.creator | Rivarola, Hector Walter | - |
| dc.creator | Sosa Escudero, Miguel Angel | - |
| dc.date | 2016-05-24T18:59:31Z | - |
| dc.date | 2016-05-24T18:59:31Z | - |
| dc.date | 2015-09-02 | - |
| dc.date | 2016-05-16T20:09:39Z | - |
| dc.date.accessioned | 2019-04-29T15:40:16Z | - |
| dc.date.available | 2019-04-29T15:40:16Z | - |
| dc.date.issued | 2016-05-24T18:59:31Z | - |
| dc.date.issued | 2016-05-24T18:59:31Z | - |
| dc.date.issued | 2015-09-02 | - |
| dc.date.issued | 2016-05-16T20:09:39Z | - |
| dc.identifier | Lozano, Esteban Sebastián; Strauss, Mariana; Spina Zapata, Renata María; Cifuente, Diego Alberto; Tonn, Carlos Eugenio; et al.; The in vivo trypanocidal effect of the diterpene 5-epi-icetexone obtained from Salvia gilliesii; Elsevier Ireland; Parasitology International; 65; 1; 2-9-2015; 23-26 | - |
| dc.identifier | 1383-5769 | - |
| dc.identifier | http://hdl.handle.net/11336/5818 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/299073 | - |
| dc.description | The search for new compounds with trypanocidal activity is crucial for the treatment of Chagas' disease. Previous in vitro studies have shown that the diterpene 5-epi-icetexone (ICTX) is active against Trypanosoma cruzi. The aim of this work was to evaluate the effect of ICTX on the parasites in infected mice, in an experimental model that mimics the acute phase of the disease. Swiss albino mice were infected with T. cruzi and treated daily with 10 mg/kg/day ICTX (i.p.). Infected mice and mice injected with either saline or the vehicle DMSO were used as controls. Animals' survival and parasitemia were monitored once a week and histological studies were made at necropsy by the 5th week after infection. It was observed that the administration of ICTX increased the survival of mice infected, and induced a significant decrease in the parasitemia, as compared to controls. A similar protective effect was observed when animals were treated orally with benznidazole (BZN, used as a control of antiparasitic effect). By the 5th week post-infection, the presence of amastigote nests was observed within the fibers of the cardiac and skeletal muscle in controls, but not in animals treated with either ICTX or BZN. In addition, inflammatory infiltrates were observed in the tissues of controls, but not in animals treated with the drugs. We conclude that ICTX has an antiparasitic effect against T. cruzi, thus constituting an interesting option for the treatment of Chagas' disease, alone or combined with other drugs. | - |
| dc.description | Fil: Lozano, Esteban Sebastián. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Mendoza. Instituto Histologia y Embriologia de Mendoza "Dr. M. Burgos"; Argentina | - |
| dc.description | Fil: Strauss, Mariana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina | - |
| dc.description | Fil: Spina Zapata, Renata María. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Mendoza. Instituto Histologia y Embriologia de Mendoza "Dr. M. Burgos"; Argentina | - |
| dc.description | Fil: Cifuente, Diego Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones en Tecnología Química; Argentina | - |
| dc.description | Fil: Tonn, Carlos Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones en Tecnología Química; Argentina | - |
| dc.description | Fil: Rivarola, Hector Walter. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina | - |
| dc.description | Fil: Sosa Escudero, Miguel Angel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Mendoza. Instituto Histologia y Embriologia de Mendoza "Dr. M. Burgos"; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Elsevier Ireland | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1383576915001439 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.parint.2015.08.011 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/10.1016/j.parint.2015.08.011 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | CHAGAS¨DISEASE | - |
| dc.subject | TRYPANOSOMA CRUZI | - |
| dc.subject | NATURAL COMPOUNDS | - |
| dc.subject | DITERPENES | - |
| dc.subject | Parasitología | - |
| dc.subject | Ciencias de la Salud | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | The in vivo trypanocidal effect of the diterpene 5-epi-icetexone obtained from Salvia gilliesii | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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