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dc.creatorMeyer, Maria-
dc.creatorGonzalez Deniselle, Maria Claudia-
dc.creatorGaray, Laura Ines-
dc.creatorSitruk Ware, Regine-
dc.creatorGuennoun, Rachida-
dc.creatorde Nicola, Alejandro Federico-
dc.date2017-08-25T20:52:35Z-
dc.date2017-08-25T20:52:35Z-
dc.date2015-11-12-
dc.date2017-08-09T16:57:32Z-
dc.date.accessioned2019-04-29T15:40:22Z-
dc.date.available2019-04-29T15:40:22Z-
dc.date.issued2017-08-25T20:52:35Z-
dc.date.issued2017-08-25T20:52:35Z-
dc.date.issued2015-11-12-
dc.date.issued2017-08-09T16:57:32Z-
dc.identifierMeyer, Maria; Gonzalez Deniselle, Maria Claudia; Garay, Laura Ines; Sitruk Ware, Regine; Guennoun, Rachida; et al.; The Progesterone receptor agonist Nestorone holds back proinflammatory mediators and neuropathology in Wobbler Mouse motoneuron degeneration; Elsevier; Neuroscience; 308; 12-11-2015; 51-63-
dc.identifier0306-4522-
dc.identifierhttp://hdl.handle.net/11336/23052-
dc.identifier1873-7544-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/299130-
dc.descriptionWobbler mutant mice suffer from progressive motoneuron degeneration and glial cell reactivity in the spinal cord. To prevent development of these abnormalities, we employed Nestorone, a high-affinity progesterone receptor agonist endowed with neuroprotective, promyelinating and anti-inflammatory activities in experimental brain ischemia, preventing neuroinflammation and chemical degeneration. Five-month-old Wobbler mice (wr-/wr-) received s.c. injections of 200μg/day/mouse of Nestorone in vegetable oil or vehicle for 10days. Control NFR/NFR mice (background strain for Wobbler) received vehicle only. Vehicle-treated Wobblers showed typical spinal cord abnormalities, such as vacuolated motoneurons, decreased immunoreactive choline-acetyltransferase, decreased expression of glutamine synthase (GS), increased glial fibrillary acidic protein-positive (GFAP) astrogliosis and curved digits in forelimbs. These cell-specific abnormalities were normalized in Nestorone-treated Wobblers. In addition, vehicle-treated Wobblers showed Iba1+ microgliosis, high expression of the microglial marker CD11b mRNA and up-regulation of the proinflammatory markers TNFα and iNOS mRNAs. In Nestorone-treated Wobblers, Iba1+ microgliosis subsided, whereas CD11b, TNFα and iNOS mRNAs were down-regulated. NFκB mRNA was increased in Wobbler spinal cord and decreased by Nestorone, whereas expression of its inhibitor IκBα was increased in Nestorone-treated Wobblers compared to control mice and vehicle-treated Wobblers. In conclusion, our results showed that Nestorone restraining effects on proinflammatory mediators, microgliosis and astrogliosis may support neurons in their resistance against degenerative processes-
dc.descriptionFil: Meyer, Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina-
dc.descriptionFil: Gonzalez Deniselle, Maria Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina-
dc.descriptionFil: Garay, Laura Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina-
dc.descriptionFil: Sitruk Ware, Regine. The Rockefeller University; Estados Unidos. Population Council; Estados Unidos-
dc.descriptionFil: Guennoun, Rachida. Inserm; Francia. Universite Paris Sud; Francia-
dc.descriptionFil: de Nicola, Alejandro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina-
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dc.languageeng-
dc.publisherElsevier-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0306452215008179-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.neuroscience.2015.09.007-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectWOBBLER-
dc.subjectPROGESTERONE-
dc.subjectSPINAL CORD-
dc.subjectGLIOSIS-
dc.subjectASTROCYTES-
dc.subjectBioquímica y Biología Molecular-
dc.subjectMedicina Básica-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.titleThe Progesterone receptor agonist Nestorone holds back proinflammatory mediators and neuropathology in Wobbler Mouse motoneuron degeneration-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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