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dc.creatorGrewal, Prabhjit K.-
dc.creatorAziz, Peter V.-
dc.creatorUchiyama, Satoshi-
dc.creatorRubio, Gabriel R.-
dc.creatorLardone, Ricardo Dante-
dc.creatorLe, Dzung-
dc.creatorVarki, Nissi M.-
dc.creatorNizet, Victor-
dc.creatorMarth, Jamey D.-
dc.date2017-10-06T18:26:19Z-
dc.date2017-10-06T18:26:19Z-
dc.date2013-12-
dc.date2017-10-05T20:41:03Z-
dc.date.accessioned2019-04-29T15:40:27Z-
dc.date.available2019-04-29T15:40:27Z-
dc.date.issued2017-10-06T18:26:19Z-
dc.date.issued2017-10-06T18:26:19Z-
dc.date.issued2013-12-
dc.date.issued2017-10-05T20:41:03Z-
dc.identifierGrewal, Prabhjit K.; Aziz, Peter V.; Uchiyama, Satoshi; Rubio, Gabriel R.; Lardone, Ricardo Dante; et al.; Inducing host protection in pneumococcal sepsis by preactivation of the Ashwell-Morell receptor; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 110; 50; 12-2013; 20218-20223-
dc.identifier0027-8424-
dc.identifierhttp://hdl.handle.net/11336/26107-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/299169-
dc.descriptionThe endocytic Ashwell-Morell receptor (AMR) of hepatocytes detects pathogen remodeling of host glycoproteins by neuraminidase in the bloodstream and mitigates the lethal coagulopathy of sepsis. We have investigated the mechanism of host protection by the AMR during the onset of sepsis and in response to the desialylation of blood glycoproteins by the NanA neuraminidase of Streptococcus pneumoniae. We find that the AMR selects among potential glycoprotein ligands unmasked by microbial neuraminidase activity in pneumococcal sepsis to eliminate from blood circulation host factors that contribute to coagulation and thrombosis. This protection is attributable in large part to the rapid induction of a moderate thrombocytopenia by the AMR. We further show that neuraminidase activity in the blood can be manipulated to induce the clearance of AMR ligands including platelets, thereby preactivating a protective response in pneumococcal sepsis that moderates the severity of disseminated intravascular coagulation and enables host survival.-
dc.descriptionFil: Grewal, Prabhjit K.. University of California; Estados Unidos. Sanford-burnham Medical Research Institute; Estados Unidos-
dc.descriptionFil: Aziz, Peter V.. University of California; Estados Unidos. Sanford-burnham Medical Research Institute; Estados Unidos-
dc.descriptionFil: Uchiyama, Satoshi. University of California at San Diego; Estados Unidos-
dc.descriptionFil: Rubio, Gabriel R.. University of California; Estados Unidos. Sanford-burnham Medical Research Institute; Estados Unidos-
dc.descriptionFil: Lardone, Ricardo Dante. University of California; Estados Unidos. Sanford-burnham Medical Research Institute; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Le, Dzung. University of California at San Diego; Estados Unidos-
dc.descriptionFil: Varki, Nissi M.. University of California at San Diego; Estados Unidos-
dc.descriptionFil: Nizet, Victor. University of California at San Diego; Estados Unidos-
dc.descriptionFil: Marth, Jamey D.. University of California; Estados Unidos. Sanford-burnham Medical Research Institute; Estados Unidos-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherNational Academy of Sciences-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1073/pnas.1313905110-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.pnas.org/content/110/50/20218-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864324/-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectGlycosyation-
dc.subjectCoagulopathy-
dc.subjectSepsis-
dc.subjectBioquímica y Biología Molecular-
dc.subjectMedicina Básica-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.titleInducing host protection in pneumococcal sepsis by preactivation of the Ashwell-Morell receptor-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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