Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | de Paula, Karina | - |
| dc.creator | Camí, Gerardo Enrique | - |
| dc.creator | Brusau, Elena Virginia | - |
| dc.creator | Narda, Griselda Edith | - |
| dc.creator | Ellena, Javier | - |
| dc.date | 2015-09-30T15:54:17Z | - |
| dc.date | 2015-09-30T15:54:17Z | - |
| dc.date | 2013-07-29 | - |
| dc.date | 2016-03-30 10:35:44.97925-03 | - |
| dc.date.accessioned | 2019-04-29T15:40:44Z | - |
| dc.date.available | 2019-04-29T15:40:44Z | - |
| dc.date.issued | 2015-09-30T15:54:17Z | - |
| dc.date.issued | 2015-09-30T15:54:17Z | - |
| dc.date.issued | 2013-07-29 | - |
| dc.date.issued | 2016-03-30 10:35:44.97925-03 | - |
| dc.identifier | de Paula, Karina; Camí, Gerardo Enrique; Brusau, Elena Virginia; Narda, Griselda Edith; Ellena, Javier; Mebendazole Mesylate Monohydrate: A New Route to Improve the Solubility of Mebendazole Polymorphs; Wiley; Journal of Pharmaceutical Sciences; 102; 10; 29-7-2013; 3528-3538 | - |
| dc.identifier | 1520-6017 | - |
| dc.identifier | http://hdl.handle.net/11336/2209 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/299299 | - |
| dc.description | Mebendazole mesylate monohydrate, a new stable salt of mebendazole (MBZ), has been synthesized and fully characterized. It was obtained from recrystallization of MBZ forms A, B, or C in diverse solvents with the addition of methyl sulfonic acid solution. The crystal packing is first organized as a two-dimensional array consisting of rows of alternating MBZ molecules linked to columns of mesylate ions by hydrogen bonds. The three-dimensional structure is further developed by classical intermolecular interactions involving water molecules. In addition, nonclassical contacts are also found. The vibrational behavior is consistent with the crystal structure, the most important functional groups showing shifts to lower or higher frequencies in relation to the MBZ polymorphs. Thermal analysis indicates that the compound is stable up to 50◦C. Decomposition occurs in five steps. Solubility studies show that the title compound presents a significant higher performance than polymorph C. | - |
| dc.description | Fil: de Paula, Karina. Universidade of São Paulo. Physics Instituto of Sao Carlos; Brasil; | - |
| dc.description | Fil: Camí, Gerardo Enrique. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Laboratorio de Química Inorgánica; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones en Tecnología Química; Argentina; | - |
| dc.description | Fil: Brusau, Elena Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones en Tecnología Química; Argentina; | - |
| dc.description | Fil: Narda, Griselda Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones en Tecnología Química; Argentina; | - |
| dc.description | Fil: Ellena, Javier. Universidade of São Paulo. Physics Instituto of Sao Carlos; Brasil; | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Wiley | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/jps.23658/abstract | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/DOI:10.1002/jps.23658 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | Mebendazole mesylate | - |
| dc.subject | Solid state | - |
| dc.subject | Crystal structure | - |
| dc.subject | FTIR-Raman spectroscopy | - |
| dc.subject | Thermal stability | - |
| dc.subject | Dissolution | - |
| dc.subject | Físico-Química, Ciencia de los Polímeros, Electroquímica | - |
| dc.subject | Ciencias Químicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Mebendazole Mesylate Monohydrate: A New Route to Improve the Solubility of Mebendazole Polymorphs | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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