Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Pardo, Joaquin | - |
| dc.creator | Abba, Martín Carlos | - |
| dc.creator | Lacunza, Ezequiel | - |
| dc.creator | Ogundele, Olalekan Michael | - |
| dc.creator | Paiva, Isabel | - |
| dc.creator | Morel, Gustavo Ramón | - |
| dc.creator | Outeiro, Tiago F. | - |
| dc.creator | Goya, Rodolfo Gustavo | - |
| dc.date | 2018-06-23T22:38:31Z | - |
| dc.date | 2018-06-23T22:38:31Z | - |
| dc.date | 2017-06 | - |
| dc.date | 2018-06-13T14:55:54Z | - |
| dc.date.accessioned | 2019-04-29T15:40:53Z | - |
| dc.date.available | 2019-04-29T15:40:53Z | - |
| dc.date.issued | 2018-06-23T22:38:31Z | - |
| dc.date.issued | 2018-06-23T22:38:31Z | - |
| dc.date.issued | 2017-06 | - |
| dc.date.issued | 2018-06-13T14:55:54Z | - |
| dc.identifier | Pardo, Joaquin; Abba, Martín Carlos; Lacunza, Ezequiel; Ogundele, Olalekan Michael; Paiva, Isabel; et al.; IGF-I Gene Therapy in Aging Rats Modulates Hippocampal Genes Relevant to Memory Function; Gerontological Soc Amer; Journals Of Gerontology Series A-biological Sciences And Medical Sciences; 72; 4; 6-2017; 459-467 | - |
| dc.identifier | 1079-5006 | - |
| dc.identifier | http://hdl.handle.net/11336/49870 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/299371 | - |
| dc.description | In rats, learning and memory performance decline during normal aging, which makes this rodent species a suitable model to evaluate therapeutic strategies. In aging rats, insulin-like growth factor-I (IGF-I), is known to significantly improve spatial memory accuracy as compared to control counterparts. A constellation of gene expression changes underlie the hippocampal phenotype of aging but no studies on the effects of IGF-I on the hippocampal transcriptome of old rodents have been documented. Here, we assessed the effects of IGF-I gene therapy on spatial memory performance in old female rats and compared them with changes in the hippocampal transcriptome. In the Barnes maze test, experimental rats showed a significantly higher exploratory frequency of the goal hole than controls. Hippocampal RNA-sequencing showed that 219 genes are differentially expressed in 28 months old rats intracerebroventricularly injected with an adenovector expressing rat IGF-I as compared with placebo adenovector-injected counterparts. From the differentially expressed genes, 81 were down and 138 upregulated. From those genes, a list of functionally relevant genes, concerning hippocampal IGF-I expression, synaptic plasticity as well as neuronal function was identified. Our results provide an initial glimpse at the molecular mechanisms underlying the neuroprotective actions of IGF-I in the aging brain. | - |
| dc.description | Fil: Pardo, Joaquin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina | - |
| dc.description | Fil: Abba, Martín Carlos. Universidad Nacional de La Plata; Argentina | - |
| dc.description | Fil: Lacunza, Ezequiel. Universidad Nacional de La Plata; Argentina | - |
| dc.description | Fil: Ogundele, Olalekan Michael. State University of Louisiana; Estados Unidos | - |
| dc.description | Fil: Paiva, Isabel. Universität Göttingen; Alemania | - |
| dc.description | Fil: Morel, Gustavo Ramón. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina | - |
| dc.description | Fil: Outeiro, Tiago F.. Universität Göttingen; Alemania. Max Planck Institute for Experimental Medicine; Alemania | - |
| dc.description | Fil: Goya, Rodolfo Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Gerontological Soc Amer | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1093/gerona/glx125 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/biomedgerontology/article-abstract/73/4/459/3884478?redirectedFrom=fulltext | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | IGF1 | - |
| dc.subject | BRAIN | - |
| dc.subject | GENE EXPRESSION | - |
| dc.subject | NGS | - |
| dc.subject | Otras Ciencias Biológicas | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | IGF-I Gene Therapy in Aging Rats Modulates Hippocampal Genes Relevant to Memory Function | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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