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dc.creatorGuisoni, Nara Cristina-
dc.creatorMonteoliva, D.-
dc.creatorDiambra, Luis Anibal-
dc.date2018-06-08T19:29:12Z-
dc.date2018-06-08T19:29:12Z-
dc.date2016-03-
dc.date2018-06-08T14:26:59Z-
dc.date.accessioned2019-04-29T15:41:03Z-
dc.date.available2019-04-29T15:41:03Z-
dc.date.issued2018-06-08T19:29:12Z-
dc.date.issued2018-06-08T19:29:12Z-
dc.date.issued2016-03-
dc.date.issued2018-06-08T14:26:59Z-
dc.identifierGuisoni, Nara Cristina; Monteoliva, D.; Diambra, Luis Anibal; Promoters Architecture-Based Mechanism for Noise-Induced Oscillations in a Single-Gene Circuit; Public Library of Science; Plos One; 11; 3; 3-2016; 1-12; e0151086-
dc.identifierhttp://hdl.handle.net/11336/47956-
dc.identifier1932-6203-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/299451-
dc.descriptionIt is well known that single-gene circuits with negative feedback loop can lead to oscillatory gene expression when they operate with time delay. In order to generate these oscillations many processes can contribute to properly timing such delay. Here we show that the time delay coming from the transitions between internal states of the cis-regulatory system (CRS) can drive sustained oscillations in an auto-repressive single-gene circuit operating in a small volume like a cell. We found that the cooperative binding of repressor molecules is not mandatory for a oscillatory behavior if there are enough binding sites in the CRS. These oscillations depend on an adequate balance between the CRS kinetic, and the synthesis/degradation rates of repressor molecules. This finding suggest that the multi-site CRS architecture can play a key role for oscillatory behavior of gene expression. Finally, our results can also help to synthetic biologists on the design of the promoters architecture for new genetic oscillatory circuits.-
dc.descriptionFil: Guisoni, Nara Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; Argentina-
dc.descriptionFil: Monteoliva, D.. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Física; Argentina-
dc.descriptionFil: Diambra, Luis Anibal. Universidad Nacional de La Plata. Centro Regional de Estudios Genómicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherPublic Library of Science-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0151086-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1371/journal.pone.0151086-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectGENE CIRCUIT-
dc.subjectNEGATIVE FEEDBACK-
dc.subjectCOOPERATIVITY-
dc.subjectNOISE-INDUCED OSCILLATIONS-
dc.subjectOtras Ciencias Biológicas-
dc.subjectCiencias Biológicas-
dc.subjectCIENCIAS NATURALES Y EXACTAS-
dc.titlePromoters Architecture-Based Mechanism for Noise-Induced Oscillations in a Single-Gene Circuit-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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