Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Arendrup, Maiken Cavling | - |
| dc.creator | Rodriguez Tudela, Juan Luis | - |
| dc.creator | Park, Steven | - |
| dc.creator | Garcia, Guillermo Manuel | - |
| dc.creator | Delmas, Guillaume | - |
| dc.creator | Cuenca Estrella, Manuel | - |
| dc.creator | Gómez López, Alicia | - |
| dc.creator | Perlin, David Scott | - |
| dc.date | 2017-04-18T15:34:52Z | - |
| dc.date | 2017-04-18T15:34:52Z | - |
| dc.date | 2011-01 | - |
| dc.date | 2017-03-22T15:20:19Z | - |
| dc.date.accessioned | 2019-04-29T15:41:04Z | - |
| dc.date.available | 2019-04-29T15:41:04Z | - |
| dc.date.issued | 2017-04-18T15:34:52Z | - |
| dc.date.issued | 2017-04-18T15:34:52Z | - |
| dc.date.issued | 2011-01 | - |
| dc.date.issued | 2017-03-22T15:20:19Z | - |
| dc.identifier | Arendrup, Maiken Cavling; Rodriguez Tudela, Juan Luis; Park, Steven; Garcia, Guillermo Manuel; Delmas, Guillaume; et al.; Echinocandin susceptibility testing of Candida spp. using the EUCAST EDef 7.1 and CLSI M27-A3 standard procedures: Analysis of the influence of Bovine Serum Albumin Supplementation, Storage Time and Drug Lots; American Society For Microbiology; Antimicrobial Agents And Chemotherapy; 55; 4; 1-2011; 1580-1587 | - |
| dc.identifier | 0066-4804 | - |
| dc.identifier | http://hdl.handle.net/11336/15355 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/299459 | - |
| dc.description | The MICs of echinocandins against Candida isolates with fks mutations are higher than those for wild-type (WT) isolates. However, the MIC ranges for susceptible and mutant populations overlap or are poorly separated. It was recently reported that a greater separation could be achieved in the presence of serum. To more fully explore this possibility, we compared the performances of the reference microdilution methods by using standard and bovine serum albumin (BSA)-supplemented growth medium. Anidulafungin, caspofungin, and micafungin MICs were determined according to EUCAST and CLSI methods and with 50% BSA in the medium for 93 clinical isolates, including Candida albicans (20/10 [number of isolates/number of mutants]), C. glabrata (19/10), C. dubliniensis (2/1), C. krusei (16/3), C. parapsilosis (19), and C. tropicalis (19/4) isolates. Stability of the plates was tested after storage at -80°C for 2 and 6 months, and the performance of two different lots of caspofungin was investigated. The addition of BSA to the medium resulted in higher MICs (1 to 9 2-fold dilution steps) for all isolates and compounds. The increases were greatest for anidulafungin and micafungin and, among WT isolates, for C. parapsilosis. The number of very major errors (VMEs) was reduced (24% [20/84 isolates] versus ≤ 7% [6/84 isolates]) using BSA-supplemented EUCAST medium but not using BSA-supplemented CLSI medium (6% versus 9%). MIC results were unchanged after 6 months of storage of test plates. The two lots of caspofungin yielded identical results. Addition of BSA to the EUCAST medium increases the ability to differentiate between WT isolates and isolates harboring resistance mutations. | - |
| dc.description | Fil: Arendrup, Maiken Cavling. Statens Serum Institut. Unit of Mycology and Parasitology; Dinamarca | - |
| dc.description | Fil: Rodriguez Tudela, Juan Luis. Instituto de Salud Carlos III. Centro Nacional de Microbiología. Servicio de Micología; España | - |
| dc.description | Fil: Park, Steven. UMDNJ-New Jersey Medical School. Public Health Research Institute; Estados Unidos | - |
| dc.description | Fil: Garcia, Guillermo Manuel. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina. UMDNJ-New Jersey Medical School. Public Health Research Institute; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe; Argentina | - |
| dc.description | Fil: Delmas, Guillaume. UMDNJ-New Jersey Medical School. Public Health Research Institute; Estados Unidos | - |
| dc.description | Fil: Cuenca Estrella, Manuel. Instituto de Salud Carlos III. Centro Nacional de Microbiología. Servicio de Micología; España | - |
| dc.description | Fil: Gómez López, Alicia. Instituto de Salud Carlos III. Centro Nacional de Microbiología. Servicio de Micología; España | - |
| dc.description | Fil: Perlin, David Scott. UMDNJ-New Jersey Medical School. Public Health Research Institute; Estados Unidos | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | American Society For Microbiology | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1128/AAC.01364-10 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3067145/ | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://aac.asm.org/content/55/4/1580 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | Candida | - |
| dc.subject | Susceptibility testing | - |
| dc.subject | Resistance | - |
| dc.subject | Echinocandins | - |
| dc.subject | Enfermedades Infecciosas | - |
| dc.subject | Ciencias de la Salud | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Echinocandin susceptibility testing of Candida spp. using the EUCAST EDef 7.1 and CLSI M27-A3 standard procedures: Analysis of the influence of Bovine Serum Albumin Supplementation, Storage Time and Drug Lots | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
Ficheros en este ítem:
No hay ficheros asociados a este ítem.