Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | CONICET | - |
| dc.creator | Sommer, Lea M. | - |
| dc.creator | Marvig, Rasmus L. | - |
| dc.creator | Lujan, Adela Maria | - |
| dc.creator | Koza, Anna | - |
| dc.creator | Pressler, Tacjana | - |
| dc.creator | Molin, Soeren | - |
| dc.creator | Johansen, Helle K | - |
| dc.date | 2018-07-02T17:13:12Z | - |
| dc.date | 2018-07-02T17:13:12Z | - |
| dc.date | 2016-08 | - |
| dc.date | 2018-06-29T16:44:46Z | - |
| dc.date.accessioned | 2019-04-29T15:41:10Z | - |
| dc.date.available | 2019-04-29T15:41:10Z | - |
| dc.date.issued | 2018-07-02T17:13:12Z | - |
| dc.date.issued | 2018-07-02T17:13:12Z | - |
| dc.date.issued | 2016-08 | - |
| dc.date.issued | 2018-06-29T16:44:46Z | - |
| dc.identifier | Sommer, Lea M. ; Marvig, Rasmus L. ; Lujan, Adela Maria; Koza, Anna ; Pressler, Tacjana ; et al.; Is genotyping of single isolates sufficient for population structure analysis of Pseudomonas aeruginosa in cystic fibrosis airways?; BioMed Central; BMC Genomics; 17; 1; 8-2016 | - |
| dc.identifier | 1471-2164 | - |
| dc.identifier | http://hdl.handle.net/11336/50850 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/299495 | - |
| dc.description | The primary cause of morbidity and mortality in cystic fibrosis (CF) patients is lung infection by Pseudomonas aeruginosa. Therefore much work has been done to understand the adaptation and evolution of P. aeruginosa in the CF lung. However, many of these studies have focused on longitudinally collected single isolates, and only few have included cross-sectional analyses of entire P. aeruginosa populations in sputum samples. To date only few studies have used the approach of metagenomic analysis for the purpose of investigating P. aeruginosa populations in CF airways. Results: We analysed five metagenomes together with longitudinally collected single isolates from four recently chronically infected CF patients. With this approach we were able to link the clone type and the majority of SNP profiles of the single isolates to that of the metagenome(s) for each individual patient. Conclusion: Based on our analysis we find that when having access to comprehensive collections of longitudinal single isolates it is possible to rediscover the genotypes of the single isolates in the metagenomic samples. This suggests that information gained from genome sequencing of comprehensive collections of single isolates is satisfactory for many investigations of adaptation and evolution of P. aeruginosa to the CF airways. | - |
| dc.description | Fil: Sommer, Lea M.. Technical University of Denmark; Dinamarca. Rigshospitalet. Department of Clinical Microbiology; Dinamarca | - |
| dc.description | Fil: Marvig, Rasmus L.. Rigshospitalet. Department of Clinical Microbiology; Dinamarca | - |
| dc.description | Fil: Lujan, Adela Maria. University of Exeter; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina | - |
| dc.description | Fil: Koza, Anna. Technical University of Denmark; Dinamarca | - |
| dc.description | Fil: Pressler, Tacjana. Rigshospitalet. Department of Clinical Microbiology; Dinamarca | - |
| dc.description | Fil: Molin, Soeren. Rigshospitalet. Department of Clinical Microbiology; Dinamarca | - |
| dc.description | Fil: Johansen, Helle K. Rigshospitalet. Department of Clinical Microbiology; Dinamarca | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | BioMed Central | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1186/s12864-016-2873-1 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-016-2873-1 | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/61079 | - |
| dc.subject | CYSTIC FIBROSIS | - |
| dc.subject | LONGITUDINAL ISOLATES | - |
| dc.subject | METAGENOMICS | - |
| dc.subject | PSEUDOMONAS AERUGINOSA | - |
| dc.subject | Otras Ciencias Biológicas | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Is genotyping of single isolates sufficient for population structure analysis of Pseudomonas aeruginosa in cystic fibrosis airways? | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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