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| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | CONICET | - |
| dc.creator | Zingales, Bianca | - |
| dc.creator | Miles, Michael A. | - |
| dc.creator | Moraes, Carolina B. | - |
| dc.creator | Luquetti, Alejandro | - |
| dc.creator | Guhl, Felipe | - |
| dc.creator | Schijman, Alejandro Gabriel | - |
| dc.creator | Ribeiro, Isabela | - |
| dc.date | 2016-02-03T20:18:38Z | - |
| dc.date | 2016-02-03T20:18:38Z | - |
| dc.date | 2014-09 | - |
| dc.date | 2016-03-30 10:35:44.97925-03 | - |
| dc.date.accessioned | 2019-04-29T15:41:16Z | - |
| dc.date.available | 2019-04-29T15:41:16Z | - |
| dc.date.issued | 2016-02-03T20:18:38Z | - |
| dc.date.issued | 2016-02-03T20:18:38Z | - |
| dc.date.issued | 2014-09 | - |
| dc.date.issued | 2016-03-30 10:35:44.97925-03 | - |
| dc.identifier | Zingales, Bianca; Miles, Michael A.; Moraes, Carolina B.; Luquetti, Alejandro; Guhl, Felipe; et al.; Drug discovery for Chagas disease should consider Trypanosoma cruzi strain diversity; Fundacao Oswaldo Cruz; Memórias Do Instituto Oswaldo Cruz; 109; 6; 9-2014; 828-833 | - |
| dc.identifier | 0074-0276 | - |
| dc.identifier | http://hdl.handle.net/11336/4003 | - |
| dc.identifier | 1678-8060 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/299542 | - |
| dc.description | This opinion piece presents an approach to standardisation of an important aspect of Chagas disease drug discovery and development: selecting Trypanosoma cruzi strains for in vitro screening. We discuss the rationale for strain selection representing T. cruzi diversity and provide recommendations on the preferred parasite stage for drug discovery, T. cruzi discrete typing units to include in the panel of strains and the number of strains/clones for primary screens and lead compounds. We also consider experimental approaches for in vitro drug assays. The Figure illustrates the current Chagas disease drug-discovery and development landscape. | - |
| dc.description | Fil: Zingales, Bianca. Universidade de São Paulo. Instituto de Química; Brasil | - |
| dc.description | Fil: Miles, Michael A.. London School of Hygiene and Tropical Medicine. Faculty of Infectious and Tropical Diseases; Reino Unido | - |
| dc.description | Fil: Moraes, Carolina B.. Centro Nacional de Pesquisa em Energias e Matérias. Laboratório Nacional de Biociências; Brasil | - |
| dc.description | Fil: Luquetti, Alejandro. Universidade Federal de Goiás. Hospital das Clínicas; Brasil | - |
| dc.description | Fil: Guhl, Felipe. Universidad de los Andes. Facultad de Ciencias. Centro de Investigaciones en Microbiología y Parasitología Tropical; Colombia | - |
| dc.description | Fil: Schijman, Alejandro Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; Argentina | - |
| dc.description | Fil: Ribeiro, Isabela. Drugs for Neglected Disease initiative; Suiza | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Fundacao Oswaldo Cruz | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000600828&lng=en&nrm=iso&tlng=en | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1590/0074-0276140156 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/issn/0074-0276 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://memorias.ioc.fiocruz.br/issues/past-issues/item/1719-0156_drug-discovery-for-chagas-disease-should-consider-trypanosoma-cruzi-strain-diversity | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/61834 | - |
| dc.subject | In vitro drug screening | - |
| dc.subject | T. cruzi genetic diversity | - |
| dc.subject | Guidelines | - |
| dc.subject | Medicina Tropical | - |
| dc.subject | Ciencias de la Salud | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.subject | Biología Celular, Microbiología | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Drug discovery for Chagas disease should consider Trypanosoma cruzi strain diversity | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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