Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | CONICET | - |
| dc.creator | Leimgruber, Carolina | - |
| dc.creator | Quintar, Amado Alfredo | - |
| dc.creator | Peinetti, Nahuel | - |
| dc.creator | Scalerandi, María Victoria | - |
| dc.creator | Nicola, Juan Pablo | - |
| dc.creator | Miano, Joseph M. | - |
| dc.creator | Maldonado, Cristina Alicia | - |
| dc.date | 2018-08-31T15:03:24Z | - |
| dc.date | 2018-08-31T15:03:24Z | - |
| dc.date | 2017-03 | - |
| dc.date | 2018-08-29T18:38:11Z | - |
| dc.date.accessioned | 2019-04-29T15:41:24Z | - |
| dc.date.available | 2019-04-29T15:41:24Z | - |
| dc.date.issued | 2018-08-31T15:03:24Z | - |
| dc.date.issued | 2018-08-31T15:03:24Z | - |
| dc.date.issued | 2017-03 | - |
| dc.date.issued | 2018-08-29T18:38:11Z | - |
| dc.identifier | Leimgruber, Carolina; Quintar, Amado Alfredo; Peinetti, Nahuel; Scalerandi, María Victoria; Nicola, Juan Pablo; et al.; Testosterone rescues the De-Differentiation of smooth muscle cells through serum response factor/myocardin; Wiley-liss, Div John Wiley & Sons Inc; Journal of Cellular Physiology; 232; 10; 3-2017; 2806-2817 | - |
| dc.identifier | 0021-9541 | - |
| dc.identifier | http://hdl.handle.net/11336/57870 | - |
| dc.identifier | 1097-4652 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/299602 | - |
| dc.description | Prostatic smooth muscle cells (pSMCs) differentiation is a key factor for prostatic homeostasis, with androgens exerting multiple effects on these cells. Here, we demonstrated that the myodifferentiator complex Srf/Myocd is up-regulated by testosterone in a dose-dependent manner in primary cultures of rat pSMCs, which was associated to the increase in Acta2, Cnn1, and Lmod1 expressions. Blocking Srf or Myocd by siRNAs inhibited the myodifferentiator effect of testosterone. While LPS led to a dedifferentiated phenotype in pSMCs, characterized by down-regulation of Srf/Myocd and smooth muscle cell (SMC)-restricted genes, endotoxin treatment on Myocd-overexpressing cells did not result in phenotypic alterations. Testosterone at a physiological dose was able to restore the muscular phenotype by normalizing Srf/Myocd expression in inflammation-induced dedifferentiated pSMCs. Moreover, the androgen reestablished the proliferation rate and IL-6 secretion increased by LPS. These results provide novel evidence regarding the myodifferentiating role of testosterone on SMCs by modulating Srf/Myocd. Thus, androgens preserve prostatic SMC phenotype, which is essential to maintain the normal structure and function of the prostate. | - |
| dc.description | Fil: Leimgruber, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina | - |
| dc.description | Fil: Quintar, Amado Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina | - |
| dc.description | Fil: Peinetti, Nahuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina | - |
| dc.description | Fil: Scalerandi, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina | - |
| dc.description | Fil: Nicola, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina | - |
| dc.description | Fil: Miano, Joseph M.. University of Rochester. School of Medicine and Dentistry; Estados Unidos | - |
| dc.description | Fil: Maldonado, Cristina Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/vnd.openxmlformats-officedocument.wordprocessingml.document | - |
| dc.language | eng | - |
| dc.publisher | Wiley-liss, Div John Wiley & Sons Inc | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://doi.wiley.com/10.1002/jcp.25679 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/jcp.25679 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/45545 | - |
| dc.subject | MIOCARDINA | - |
| dc.subject | DIFERENCIACION | - |
| dc.subject | CELULAS MUSCULARES LISAS | - |
| dc.subject | PROSTATA | - |
| dc.subject | Inmunología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Testosterone rescues the De-Differentiation of smooth muscle cells through serum response factor/myocardin | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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