Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Escudero, Graciela | - |
| dc.creator | Laino, Carlos Horacio | - |
| dc.creator | Martini, Nancy | - |
| dc.creator | Echeverría, Gustavo Alberto | - |
| dc.creator | Piro, Oscar Enrique | - |
| dc.creator | Williams, Patricia Ana María | - |
| dc.creator | Ferrer, Evelina Gloria | - |
| dc.date | 2018-11-15T13:09:59Z | - |
| dc.date | 2018-11-15T13:09:59Z | - |
| dc.date | 2017-02 | - |
| dc.date | 2018-10-22T21:46:42Z | - |
| dc.date.accessioned | 2019-04-29T15:41:45Z | - |
| dc.date.available | 2019-04-29T15:41:45Z | - |
| dc.date.issued | 2017-02 | - |
| dc.identifier | Escudero, Graciela; Laino, Carlos Horacio; Martini, Nancy; Echeverría, Gustavo Alberto; Piro, Oscar Enrique; et al.; Zn(II) based novel potential drug containing sertraline as strong antidepressant agent; JSciMed Central; Annals of Medicinal Chemistry and Research; 3; 1; 2-2017 | - |
| dc.identifier | 2378-9336 | - |
| dc.identifier | http://hdl.handle.net/11336/64512 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/299763 | - |
| dc.description | A novel compound for depression treatment and other psychiatric disorders has been obtained being capable of displaying the combined benefitsof sertraline and an essential element such as zinc in order to get better antidepressant and negative side effects. Our working group has synthesized asalt formulation (SerH2)2+[ZnCl4]2- (C34H36N2Cl8Zn, sertralonium tetrachlorozincate(II)). The crystal structure was determined by X-ray diffraction methods. It crystallizes in the monoclinic P21 space group with a=7.3869(2) Å, b=13.2888(4) Å, c=19.3541(6) Å, β=96.596(3)° Å, β=91.792(4)°, and Z=2 molecules per unit cell. Their antidepressant activity in the forced swimming test (FST) proved to be stronger than the one shown by the commercial drug sertraline hydrochloride per se. Furthermore, this compound suppressed the anorexigenic effect caused by the antidepressant and showed an improvement in the assimilation time during in vitro fluorescence studies with bovine serum albumin. The results of this work have led to a patent application which was filed (Nº 20150103320) in Argentine country. | - |
| dc.description | Fil: Escudero, Graciela. Instituto de Farmacia y Bioquímica del Ceniit-unlar (centro de Investigación E Innovación Tecnológica); Argentina | - |
| dc.description | Fil: Laino, Carlos Horacio. Instituto de Farmacia y Bioquímica del Ceniit-unlar (centro de Investigación E Innovación Tecnológica); Argentina | - |
| dc.description | Fil: Martini, Nancy. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina | - |
| dc.description | Fil: Echeverría, Gustavo Alberto. Facultad de Ciencias Exactas, Universidad Nacional de la Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina | - |
| dc.description | Fil: Piro, Oscar Enrique. Facultad de Ciencias Exactas, Universidad Nacional de la Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina | - |
| dc.description | Fil: Williams, Patricia Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina | - |
| dc.description | Fil: Ferrer, Evelina Gloria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | JSciMed Central | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.jscimedcentral.com/MedicinalChemistry/medicinalchemistry-3-1017.pdf | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.jscimedcentral.com/MedicinalChemistry/currentissue.php | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | Drug design | - |
| dc.subject | Selective serotonin reuptake inhibitors | - |
| dc.subject | Sertraline derivative | - |
| dc.subject | Antidepressant | - |
| dc.subject | Bioavailability | - |
| dc.subject | Otras Ciencias Químicas | - |
| dc.subject | Ciencias Químicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Zn(II) based novel potential drug containing sertraline as strong antidepressant agent | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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