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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.creator | Ogita, Kiyokazu | - |
dc.creator | Sugiyama, Chie | - |
dc.creator | Acosta, Gabriela Beatriz | - |
dc.creator | Kuramoto, Nobuyuki | - |
dc.creator | Shuto, Makoto | - |
dc.creator | Yoneyama, Masanori | - |
dc.creator | Nakamura, Yukary | - |
dc.creator | Shiba, Tatsuo | - |
dc.creator | Yamaguchi, Taro | - |
dc.date | 2019-01-04T21:56:50Z | - |
dc.date | 2019-01-04T21:56:50Z | - |
dc.date | 2012-03 | - |
dc.date | 2019-01-04T16:33:04Z | - |
dc.date.accessioned | 2019-04-29T15:41:55Z | - |
dc.date.available | 2019-04-29T15:41:55Z | - |
dc.date.issued | 2012-03 | - |
dc.identifier | Ogita, Kiyokazu; Sugiyama, Chie; Acosta, Gabriela Beatriz; Kuramoto, Nobuyuki; Shuto, Makoto; et al.; Opposing roles of glucocorticoid receptor and mineralocorticoid receptor in trimethyltin-induced cytotoxicity in the mouse hippocampus; Elsevier Ireland; Neuroscience Letters; 511; 2; 3-2012; 116-119 | - |
dc.identifier | 0304-3940 | - |
dc.identifier | http://hdl.handle.net/11336/67494 | - |
dc.identifier | CONICET Digital | - |
dc.identifier | CONICET | - |
dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/299826 | - |
dc.description | The organotin trimethyltin (TMT) is known to cause neuronal degeneration in the murine brain. Earlier studies indicate that TMT-induced neuronal degeneration is enhanced by adrenalectomy and prevented by exogenous glucocorticoid. The aim of this study was to investigate the regulation of TMT neuroxicity by corticosterone receptors including type I (mineralocorticoid receptor, MR) and type II (glucocorticoid receptor, GR) in adult mice. The systemic injection of TMT at the dose of 2.0 or 2.8. mg/kg produced a marked elevation in the level of plasma corticosterone that was both dose and time dependent. The MR agonist aldosterone had the ability to exacerbate TMT cytotoxicity in the dentate granule cell layer, whereas its antagonist spironolactone protected neurons from TMT cytotoxicity there. In contrast, the GR antagonist mifepristone exacerbated the TMT cytotoxicity. Taken together, our data suggest TMT cytotoxicity is oppositely regulated by GR and MR signals, being exacerbated by MR activation in adult mice. © 2012 Elsevier Ireland Ltd. | - |
dc.description | Fil: Ogita, Kiyokazu. Setsunan University; Japón | - |
dc.description | Fil: Sugiyama, Chie. Setsunan University; Japón | - |
dc.description | Fil: Acosta, Gabriela Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina. Setsunan University; Japón | - |
dc.description | Fil: Kuramoto, Nobuyuki. Setsunan University; Japón | - |
dc.description | Fil: Shuto, Makoto. Setsunan University; Japón | - |
dc.description | Fil: Yoneyama, Masanori. Setsunan University; Japón | - |
dc.description | Fil: Nakamura, Yukary. Setsunan University; Japón | - |
dc.description | Fil: Shiba, Tatsuo. Setsunan University; Japón | - |
dc.description | Fil: Yamaguchi, Taro. Setsunan University; Japón | - |
dc.format | application/pdf | - |
dc.format | application/pdf | - |
dc.language | eng | - |
dc.publisher | Elsevier Ireland | - |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.neulet.2012.01.052 | - |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0304394012001218 | - |
dc.rights | info:eu-repo/semantics/restrictedAccess | - |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
dc.source | reponame:CONICET Digital (CONICET) | - |
dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
dc.source | instacron:CONICET | - |
dc.subject | GLUCOCORTICOID RECEPTOR HIPPOCAMPUS | - |
dc.subject | MINERALOCORTICOID RECEPTOR | - |
dc.subject | TRIMETHYLTIN | - |
dc.subject | Salud Ocupacional | - |
dc.subject | Ciencias de la Salud | - |
dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
dc.title | Opposing roles of glucocorticoid receptor and mineralocorticoid receptor in trimethyltin-induced cytotoxicity in the mouse hippocampus | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.type | info:ar-repo/semantics/articulo | - |
Aparece en las colecciones: | CONICET |
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