Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | del Carmen, Silvina Andrea | - |
| dc.creator | de Moreno, Maria Alejandra | - |
| dc.creator | Levit, Romina | - |
| dc.creator | Azevedo, Vasco | - |
| dc.creator | Langella, Philippe | - |
| dc.creator | Bermúdez Humarán, Luis G. | - |
| dc.creator | Leblanc, Jean Guy Joseph | - |
| dc.date | 2018-02-27T18:13:11Z | - |
| dc.date | 2018-02-27T18:13:11Z | - |
| dc.date | 2017-01 | - |
| dc.date | 2017-12-04T18:22:07Z | - |
| dc.date.accessioned | 2019-04-29T15:42:02Z | - |
| dc.date.available | 2019-04-29T15:42:02Z | - |
| dc.date.issued | 2017-01 | - |
| dc.identifier | del Carmen, Silvina Andrea; de Moreno, Maria Alejandra; Levit, Romina; Azevedo, Vasco; Langella, Philippe; et al.; Anti-cancer effect of lactic acid bacteria expressing antioxidant enzymes or IL-10 in a colorectal cancer mouse model; Elsevier Science; International Immunopharmacology; 42; 1-2017; 122-129 | - |
| dc.identifier | 1567-5769 | - |
| dc.identifier | http://hdl.handle.net/11336/37288 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/299874 | - |
| dc.description | The association between inflammatory bowel diseases and colorectal cancer is well documented. The genetic modification of lactic acid bacteria as a tool to increase the anti-inflammatory potential of these microorganisms has also been demonstrated. Thus the aim of the present work was to evaluate the anti-cancer potential of different genetically modified lactic acid bacteria (GM-LAB) producing antioxidant enzymes (catalase or superoxide dismutase) or the anti-inflammatory cytokine IL-10 (protein or DNA delivery) using a chemical induced colon cancer murine model. Dimethilhydrazine was used to induce colorectal cancer in mice. The animals received GM-LAB producing anti-oxidant enzymes, IL-10 or a mixture of different GM-LAB. Intestinal damage, enzyme activities and cytokines were evaluated and compared to the results obtained from mice that received the wild type strains from which derived the GM-LAB. All the GM-LAB assayed showed beneficial effects against colon cancer even though they exerted different mechanisms of action. The importance to select LAB with innate beneficial properties as the progenitor strain was demonstrated with the GM-LAB producing anti-oxidant enzymes. In addition, the best effects for the mixtures GM-LAB that combine different anti-inflammatory mechanism. Results indicate that mixtures of selected LAB and GM-LAB could be used as an adjunct treatment to decrease the inflammatory harmful environment associated to colorectal cancer, especially for patients with chronic intestinal inflammation who have an increased risk to develop colorectal cancer. | - |
| dc.description | Fil: del Carmen, Silvina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina | - |
| dc.description | Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina | - |
| dc.description | Fil: Levit, Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina | - |
| dc.description | Fil: Azevedo, Vasco. Universidade Federal Do Minas Gerais; | - |
| dc.description | Fil: Langella, Philippe. Institut National de la Recherche Agronomique; Francia | - |
| dc.description | Fil: Bermúdez Humarán, Luis G.. Institut National de la Recherche Agronomique; Francia | - |
| dc.description | Fil: Leblanc, Jean Guy Joseph. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Elsevier Science | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.intimp.2016.11.017 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1567576916304738 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/22633 | - |
| dc.subject | ANTI-INFLAMMATORY | - |
| dc.subject | ANTI-OXIDANT | - |
| dc.subject | CYTOKINE | - |
| dc.subject | GENETIC MODIFICATION | - |
| dc.subject | Otras Biotecnologías de la Salud | - |
| dc.subject | Biotecnología de la Salud | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Anti-cancer effect of lactic acid bacteria expressing antioxidant enzymes or IL-10 in a colorectal cancer mouse model | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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