Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Palermo, Ana María | - |
| dc.creator | Mudry, Marta Dolores | - |
| dc.date | 2017-07-18T21:01:50Z | - |
| dc.date | 2017-07-18T21:01:50Z | - |
| dc.date | 2013-07 | - |
| dc.date | 2017-07-18T15:34:04Z | - |
| dc.date.accessioned | 2019-04-29T15:42:12Z | - |
| dc.date.available | 2019-04-29T15:42:12Z | - |
| dc.date.issued | 2013-07 | - |
| dc.identifier | Palermo, Ana María; Mudry, Marta Dolores; Metronidazole Induced DNA Damage in Somatic Cells of Drosophila melanogaster; Bentham Science Publishers; Current Drug Safety; 8; 3; 7-2013; 195-198 | - |
| dc.identifier | 1574-8863 | - |
| dc.identifier | http://hdl.handle.net/11336/20871 | - |
| dc.identifier | 2212-3911 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/299952 | - |
| dc.description | The standard version of the wing somatic mutation and recombination test (SMART) in Drosophila melanogaster was employed in order to evaluate the genotoxic potential of metronidazole (MTZ) as a function of exposure concentration. MTZ was administered by chronic feeding of 3-day-old larvae with the parenteral solution at 0, 500, 1000 and 2000 μg/ml until pupation. The marker-heterozygous progeny (mwh+/+flr3) with phenotypically wild-type wings was analyzed. Non significant differences were found between control and each MTZ concentration tested for single small spots (SSS) frequencies. Large single spots (LSS) and twin spots (TS) were significantly increased with the higher dose. MTZ treatments with 1000 and 2000 μg/ml also significantly increased the frequency of Total spots. These findings suggest that MTZ is genotoxic in the present experimental conditions and induces recombinagenesis and/or gene conversion, two major mechanisms that cause loss of heterocigosity and could play an important role in tumorigenesis and carcinogenesis processes. | - |
| dc.description | Fil: Palermo, Ana María. Ministerio de Defensa. Instituto de Investigaciones Científicas y Técnicas Para la Defensa; Argentina | - |
| dc.description | Fil: Mudry, Marta Dolores. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Bentham Science Publishers | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2174/15748863113089990035 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/113920/article | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/68026 | - |
| dc.subject | DROSOPHILA | - |
| dc.subject | GENOTOXICITY | - |
| dc.subject | METRONIDAZOLE (MTZ) | - |
| dc.subject | WING SPOT ASSAY | - |
| dc.subject | Otros Tópicos Biológicos | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Metronidazole Induced DNA Damage in Somatic Cells of Drosophila melanogaster | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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