Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Labeur, Marta | - |
| dc.creator | Páez Pereda, Marcelo | - |
| dc.creator | Haedo, Mariana Raquel | - |
| dc.creator | Arzt, Eduardo Simon | - |
| dc.creator | Stalla, Günter K. | - |
| dc.date | 2019-01-29T20:22:38Z | - |
| dc.date | 2019-01-29T20:22:38Z | - |
| dc.date | 2010-09 | - |
| dc.date | 2019-01-29T18:09:27Z | - |
| dc.date.accessioned | 2019-04-29T15:42:37Z | - |
| dc.date.available | 2019-04-29T15:42:37Z | - |
| dc.date.issued | 2010-09 | - |
| dc.identifier | Labeur, Marta; Páez Pereda, Marcelo; Haedo, Mariana Raquel; Arzt, Eduardo Simon; Stalla, Günter K.; Pituitary tumors: Cell type-specific roles for BMP-4; Elsevier Ireland; Molecular and Cellular Endocrinology; 326; 1-2; 9-2010; 85-88 | - |
| dc.identifier | 0303-7207 | - |
| dc.identifier | http://hdl.handle.net/11336/68915 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/300073 | - |
| dc.description | BMP-4 plays a crucial role not only in the formation of the anterior pituitary during embryo development but also in the pathogenesis of pituitary tumors in adults. In tumor cells, BMP-4 promotes prolactin secretion and lactotroph cell proliferation through a Smad-estrogen receptor crosstalk but it inhibits ACTH production and cell proliferation of corticotrophs. In addition, BMP-4 increases GH secretion in rat pituitary tumor somatolactotroph GH3 cells and FSHβ subunit gene transcription in the murine gonadotroph cell line, LβT2. Therefore, BMP-4 has a differential role on different types of pituitary tumors: it promotes pituitary prolactinoma while it inhibits corticotroph pathogenesis in Cushing's disease. The modulation of BMP-4 also plays an important role in the therapeutic mechanism of action of bromocriptine, somatostatin analogs and retinoic acid. | - |
| dc.description | Fil: Labeur, Marta. Max Planck Institute of Psychiatry; Alemania | - |
| dc.description | Fil: Páez Pereda, Marcelo. Max Planck Institute of Psychiatry; Alemania | - |
| dc.description | Fil: Haedo, Mariana Raquel. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular. Laboratorio de Fisiología y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Arzt, Eduardo Simon. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular. Laboratorio de Fisiología y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Stalla, Günter K.. Max Planck Institute of Psychiatry; Alemania | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Elsevier Ireland | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.mce.2010.04.006 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S030372071000211X | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | ACTH | - |
| dc.subject | BMP-4 | - |
| dc.subject | PITUITARY TUMORS | - |
| dc.subject | PROLACTIN | - |
| dc.subject | RETINOIC ACID | - |
| dc.subject | TGF-Β | - |
| dc.subject | Otras Medicina Básica | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Pituitary tumors: Cell type-specific roles for BMP-4 | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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