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dc.creatorWeber, Megan L.-
dc.creatorHsin, Hong Yuan-
dc.creatorKalay, Ersan-
dc.creatorBrožková, Dana Š-
dc.creatorShimizu, Takehiko-
dc.creatorBayram, Merve-
dc.creatorDeeley, Kathleen-
dc.creatorKüchler, Erika C.-
dc.creatorForella, Jessalyn-
dc.creatorRuff, Timothy D.-
dc.creatorTrombetta, Vanessa M.-
dc.creatorSencak, Regina C.-
dc.creatorHummel, Michael-
dc.creatorBriseño Ruiz, Jessica-
dc.creatorRevu, Shankar K.-
dc.creatorGranjeiro, José M.-
dc.creatorAntunes, Leonardo S.-
dc.creatorAntunes, Livia A.-
dc.creatorAbreu, Fernanda V.-
dc.creatorCostabel, Marcelo C.-
dc.creatorTannure, Patricia N.-
dc.creatorKoruyucu, Mine-
dc.creatorPatir, Asli-
dc.creatorPoletta, Fernando Adrián-
dc.creatorMereb, Juan C.-
dc.creatorCastilla, Eduardo Enrique-
dc.creatorOrioli, Iêda M.-
dc.creatorMarazita, Mary L.-
dc.creatorOuyang, Hongjiao-
dc.creatorJayaraman, Thottala-
dc.creatorSeymen, Figen-
dc.creatorVieira, Alexandre R.-
dc.date2018-01-31T17:35:33Z-
dc.date2018-01-31T17:35:33Z-
dc.date2014-07-
dc.date2018-01-24T18:58:53Z-
dc.date.accessioned2019-04-29T15:42:45Z-
dc.date.available2019-04-29T15:42:45Z-
dc.date.issued2014-07-
dc.identifierWeber, Megan L.; Hsin, Hong Yuan; Kalay, Ersan; Brožková, Dana Š; Shimizu, Takehiko; et al.; Role of estrogen related receptor beta (ESRRB) in DFN35B hearing impairment and dental decay; BioMed Central; BMC Medical Genetics; 15; 81; 7-2014; 1-10-
dc.identifier1471-2350-
dc.identifierhttp://hdl.handle.net/11336/35190-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/300113-
dc.descriptionBACKGROUND: Congenital forms of hearing impairment can be caused by mutations in the estrogen related receptor beta (ESRRB) gene. Our initial linkage studies suggested the ESRRB locus is linked to high caries experience in humans. METHODS: We tested for association between the ESRRB locus and dental caries in 1,731 subjects, if ESRRB was expressed in whole saliva, if ESRRB was associated with the microhardness of the dental enamel, and if ESRRB was expressed during enamel development of mice. RESULTS: Two families with recessive ESRRB mutations and DFNB35 hearing impairment showed more extensive dental destruction by caries. Expression levels of ESRRB in whole saliva samples showed differences depending on sex and dental caries experience. CONCLUSIONS: The common etiology of dental caries and hearing impairment provides a venue to assist in the identification of individuals at risk to either condition and provides options for the development of new caries prevention strategies, if the associated ESRRB genetic variants are correlated with efficacy.-
dc.descriptionFil: Weber, Megan L.. University of Pittsburgh; Estados Unidos-
dc.descriptionFil: Hsin, Hong Yuan. University of Pittsburgh; Estados Unidos-
dc.descriptionFil: Kalay, Ersan. Karadeniz Technical University; Turquía-
dc.descriptionFil: Brožková, Dana Š. Charles University; República Checa. University Hospital Motol; República Checa-
dc.descriptionFil: Shimizu, Takehiko. Nihon University. School of Dentistry; Japón-
dc.descriptionFil: Bayram, Merve. Medipol Istanbul University; Turquía-
dc.descriptionFil: Deeley, Kathleen. University of Pittsburgh; Estados Unidos-
dc.descriptionFil: Küchler, Erika C.. University of Pittsburgh; Estados Unidos-
dc.descriptionFil: Forella, Jessalyn. University of Pittsburgh; Estados Unidos-
dc.descriptionFil: Ruff, Timothy D.. University of Pittsburgh; Estados Unidos-
dc.descriptionFil: Trombetta, Vanessa M.. University of Pittsburgh; Estados Unidos-
dc.descriptionFil: Sencak, Regina C.. University of Pittsburgh; Estados Unidos-
dc.descriptionFil: Hummel, Michael. University of Pittsburgh; Estados Unidos-
dc.descriptionFil: Briseño Ruiz, Jessica. University of Pittsburgh; Estados Unidos-
dc.descriptionFil: Revu, Shankar K.. University of Pittsburgh; Estados Unidos-
dc.descriptionFil: Granjeiro, José M.. Universidade Federal Fluminense; Brasil-
dc.descriptionFil: Antunes, Leonardo S.. Universidade Federal Fluminense; Brasil-
dc.descriptionFil: Antunes, Livia A.. Universidade Federal Fluminense; Brasil-
dc.descriptionFil: Abreu, Fernanda V.. Universidade Federal Fluminense; Brasil-
dc.descriptionFil: Costabel, Marcelo C.. Universidade Federal do Rio de Janeiro; Brasil-
dc.descriptionFil: Tannure, Patricia N.. Veiga de Almeida University; Brasil. Salgado de Oliveira University; Brasil-
dc.descriptionFil: Koruyucu, Mine. Istanbul University; Turquía-
dc.descriptionFil: Patir, Asli. Medipol Istanbul University; Turquía-
dc.descriptionFil: Poletta, Fernando Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Mereb, Juan C.. Estudio Colaborativo Latino Americano de Malformaciones Congénitas; Argentina-
dc.descriptionFil: Castilla, Eduardo Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Orioli, Iêda M.. Universidade Federal do Rio de Janeiro; Brasil-
dc.descriptionFil: Marazita, Mary L.. University of Pittsburgh; Estados Unidos-
dc.descriptionFil: Ouyang, Hongjiao. University of Pittsburgh; Estados Unidos-
dc.descriptionFil: Jayaraman, Thottala. University of Pittsburgh; Estados Unidos-
dc.descriptionFil: Seymen, Figen. Istanbul University; Turquía-
dc.descriptionFil: Vieira, Alexandre R.. University of Pittsburgh; Estados Unidos-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherBioMed Central-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112727/-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1186/1471-2350-15-81-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://bmcmedgenet.biomedcentral.com/articles/10.1186/1471-2350-15-81-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttps://creativecommons.org/licenses/by/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectDental development-
dc.subjectDeafness-
dc.subjectEar development-
dc.subjectLinkage disequilibrium-
dc.subjectDental caries-
dc.subjectGenetics-
dc.subjectPolymorphisms-
dc.subjectInmunología-
dc.subjectMedicina Básica-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.titleRole of estrogen related receptor beta (ESRRB) in DFN35B hearing impairment and dental decay-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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