Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Perroud, Herman Andrés | - |
| dc.creator | Rico, Maria Jose | - |
| dc.creator | Alasino, Carlos | - |
| dc.creator | Queralt, Fransisco | - |
| dc.creator | Mainetti, Leandro Ernesto | - |
| dc.creator | Pezzotto, Stella Maris | - |
| dc.creator | Rozados, Viviana Rosa | - |
| dc.creator | Scharovsky, Olga Graciela | - |
| dc.date | 2017-08-03T18:01:10Z | - |
| dc.date | 2017-08-03T18:01:10Z | - |
| dc.date | 2013-03 | - |
| dc.date | 2017-07-21T19:06:23Z | - |
| dc.date.accessioned | 2019-04-29T15:42:48Z | - |
| dc.date.available | 2019-04-29T15:42:48Z | - |
| dc.date.issued | 2013-03 | - |
| dc.identifier | Perroud, Herman Andrés; Rico, Maria Jose; Alasino, Carlos; Queralt, Fransisco ; Mainetti, Leandro Ernesto; et al.; Safety and therapeutic effect of metronomic chemotherapy with cyclophosphamide and celecoxib in advanced breast cancer patients; Future Medicine; Future Oncology; 9; 3; 3-2013; 451-462 | - |
| dc.identifier | 1479-6694 | - |
| dc.identifier | http://hdl.handle.net/11336/21817 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/300135 | - |
| dc.description | Metronomic chemotherapy (MCT), the chronic administration, at regular intervals, of low doses of chemotherapeutic drugs without extended rest periods, allows chronic treatment with therapeutic efficacy and low toxicity. Our preclinical results suggested that combined MCT with cyclophosphamide and celecoxib could inhibit breast cancer growth. The aim of this study was to determine the toxicity, safety and efficacy of oral MCT with cyclophosphamide 50 mg per orem daily and celecoxib 400 mg (200 mg per orem two-times a day) in advanced breast cancer patients. During the first stage of the study, the therapeutic response consisted of prolonged stable disease for ≥24 weeks in six out of 15 (40%) patients with a median duration of 37.5 weeks and a partial response in one out of 15 (response rate: 6.7%) patients lasting 6 weeks . The overall clinical benefit rate was 46.7%. The median time to progression was 14 weeks. Progression-free survival at 24 weeks was 40% and the 1-year overall survival rate was 46.7%. The adverse events were mild (gastric, grade 1; and hematologic, grade 1 or 2). No grade 3 or 4 toxicities were associated with the treatment. Evaluation of patients’ quality of life showed no changes during the response period. MCT with cyclophosphamide plus celecoxib is safe and shows a therapeutic effect in advanced breast cancer patients. | - |
| dc.description | Fil: Perroud, Herman Andrés. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Escuela de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Rico, Maria Jose. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Escuela de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Alasino, Carlos. Instituto de Oncología de Rosario; Argentina | - |
| dc.description | Fil: Queralt, Fransisco. Instituto de Oncología de Rosario; Argentina | - |
| dc.description | Fil: Mainetti, Leandro Ernesto. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Escuela de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Pezzotto, Stella Maris. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Escuela de Ciencias Médicas; Argentina | - |
| dc.description | Fil: Rozados, Viviana Rosa. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Escuela de Ciencias Médicas; Argentina | - |
| dc.description | Fil: Scharovsky, Olga Graciela. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Escuela de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Future Medicine | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2217/fon.12.196 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.futuremedicine.com/doi/10.2217/fon.12.196 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | BREAST CANCER | - |
| dc.subject | METRONOMIC CHEMOTHERAPY | - |
| dc.subject | CYCLOPHOSPHAMIDE | - |
| dc.subject | CELECOXIB | - |
| dc.subject | Reumatología | - |
| dc.subject | Medicina Clínica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Safety and therapeutic effect of metronomic chemotherapy with cyclophosphamide and celecoxib in advanced breast cancer patients | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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