Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Villordo, Sergio | - |
| dc.creator | Gamarnik, Andrea Vanesa | - |
| dc.date | 2016-01-26T17:18:53Z | - |
| dc.date | 2016-01-26T17:18:53Z | - |
| dc.date | 2013-08 | - |
| dc.date | 2016-03-30 10:35:44.97925-03 | - |
| dc.date.accessioned | 2019-04-29T15:42:50Z | - |
| dc.date.available | 2019-04-29T15:42:50Z | - |
| dc.date.issued | 2013-08 | - |
| dc.identifier | Villordo, Sergio; Gamarnik, Andrea Vanesa; Differential RNA sequence requirement for dengue virus replication in mosquito and mammalian cells; American Society for Microbiology; Journal Of Virology (online); 87; 16; 8-2013; 9365-9372 | - |
| dc.identifier | 1098-5514 | - |
| dc.identifier | http://hdl.handle.net/11336/3821 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/300151 | - |
| dc.description | Dengue virus cycles between mosquitoes and humans. Each host provides a different environment for viral replication, imposing different selective pressures. We identified a sequence in the dengue virus genome that is essential for viral replication in mosquito cells but not in mammalian cells. This sequence is located at the viral 3′ untranslated region and folds into a small hairpin structure. A systematic mutational analysis using dengue virus infectious clones and reporter viruses allowed the determination of two putative functions in this cis-acting RNA motif, one linked to the structure and the other linked to the nucleotide sequence. We found that single substitutions that did not alter the hairpin structure did not affect dengue virus replication in mammalian cells but abolished replication in mosquito cells. This is the first sequence identified in a flavivirus genome that is exclusively required for viral replication in insect cells. | - |
| dc.description | Fil: Villordo, Sergio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina | - |
| dc.description | Fil: Gamarnik, Andrea Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | American Society for Microbiology | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/ark/10.1128/JVI.00567-13 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1128/JVI.00567-13 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754043/ | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://jvi.asm.org/content/87/16/9365.long | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754043/ | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | RNA VIRUS | - |
| dc.subject | DENGUE VIRUS | - |
| dc.subject | HOST SPECIFIC RNA ELEMENTS | - |
| dc.subject | RNA STRUCTURE | - |
| dc.subject | Virología | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Differential RNA sequence requirement for dengue virus replication in mosquito and mammalian cells | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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