Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Mompeón, Ana | - |
| dc.creator | Lázaro Franco, Macarena | - |
| dc.creator | Bueno Betí, Carlos | - |
| dc.creator | Pérez Cremades, Daniel | - |
| dc.creator | Vidal Gómez, Xavier | - |
| dc.creator | Monsalve, Elena | - |
| dc.creator | Gironacci, Mariela Mercedes | - |
| dc.creator | Hermenegildo, Carlos | - |
| dc.creator | Novella, Susana | - |
| dc.date | 2017-06-15T17:52:47Z | - |
| dc.date | 2017-06-15T17:52:47Z | - |
| dc.date | 2016-02 | - |
| dc.date | 2017-06-15T17:36:45Z | - |
| dc.date.accessioned | 2019-04-29T15:42:51Z | - |
| dc.date.available | 2019-04-29T15:42:51Z | - |
| dc.date.issued | 2016-02 | - |
| dc.identifier | Mompeón, Ana; Lázaro Franco, Macarena; Bueno Betí, Carlos; Pérez Cremades, Daniel; Vidal Gómez, Xavier; et al.; Estradiol, acting through ERα, induces endothelial non-classic renin-angiotensin system increasing angiotensin 1-7 production.; Elsevier Ireland; Molecular And Cellular Endocrinology; 422; 2-2016; 1-8 | - |
| dc.identifier | 0303-7207 | - |
| dc.identifier | http://hdl.handle.net/11336/18259 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/300154 | - |
| dc.description | Intracellular renin-angiotensin system (RAS) can operate independently of the circulating RAS. Estrogens provide protective effects by modulating the RAS. Our aim was to investigate the effect of estradiol (E2) on angiotensin converting enzymes (ACE) 1 and ACE2 expression and activities in human endothelial cells (HUVEC), and the role of estrogen receptors (ER). The results confirmed the presence of active intracellular RAS in HUVEC. Physiological concentrations of E2 induced a concentration-dependent increase of ACE1 and ACE2 mRNA expression and ACE1, but not ACE2, protein levels. ACE1 and ACE2 enzymatic activities were also induced with E2. These effects were mediated through ERα activation, since ER antagonists ICI 182780 and MPP completely abolished the effect of E2. Moreover, the ERα agonist PPT mirrored the E2 effects on ACE1 and ACE2 protein expression and activity. Exposure of endothelial cells to E2 significantly increased Ang-(1–7) production. In conclusion, E2 increases Ang-(1–7) production, through ERα, involving increased ACE1 and ACE2 mRNA expression and activity and ACE1 protein levels. | - |
| dc.description | Fil: Mompeón, Ana. Universidad de Valencia; España | - |
| dc.description | Fil: Lázaro Franco, Macarena. Universidad de Valencia; España | - |
| dc.description | Fil: Bueno Betí, Carlos. Universidad de Valencia; España | - |
| dc.description | Fil: Pérez Cremades, Daniel. Universidad de Valencia; España | - |
| dc.description | Fil: Vidal Gómez, Xavier. Universidad de Valencia; España | - |
| dc.description | Fil: Monsalve, Elena. Universidad de Valencia; España | - |
| dc.description | Fil: Gironacci, Mariela Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica; Argentina | - |
| dc.description | Fil: Hermenegildo, Carlos. Universidad de Valencia; España | - |
| dc.description | Fil: Novella, Susana. Universidad de Valencia; España | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Elsevier Ireland | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0303720715301295 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.mce.2015.11.004 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | ESTROGEN | - |
| dc.subject | ENDOTHELIAL CELL | - |
| dc.subject | ANGIOTENSIN CONVERTING ENZYMES | - |
| dc.subject | RENIN ANGIOTENSIN SYSTEM | - |
| dc.subject | ESTROGEN RECEPTOR | - |
| dc.subject | Bioquímica y Biología Molecular | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Estradiol, acting through ERα, induces endothelial non-classic renin-angiotensin system increasing angiotensin 1-7 production. | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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