Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Kugel, Sita | - |
| dc.creator | Feldman, Jessica L. | - |
| dc.creator | Klein, Mark A. | - |
| dc.creator | Silberman, Dafne Magali | - |
| dc.creator | Sebastián, Carlos | - |
| dc.creator | Mermel, Craig | - |
| dc.creator | Dobersch, Stephanie | - |
| dc.creator | Clark, Abbe R. | - |
| dc.creator | Getz, Gad | - |
| dc.creator | Denu, John M. | - |
| dc.creator | Mostoslavsky, Raul | - |
| dc.date | 2017-03-06T20:14:42Z | - |
| dc.date | 2017-03-06T20:14:42Z | - |
| dc.date | 2015-10 | - |
| dc.date | 2017-03-06T17:07:37Z | - |
| dc.date.accessioned | 2019-04-29T15:43:02Z | - |
| dc.date.available | 2019-04-29T15:43:02Z | - |
| dc.date.issued | 2015-10 | - |
| dc.identifier | Kugel, Sita ; Feldman, Jessica L. ; Klein, Mark A.; Silberman, Dafne Magali; Sebastián, Carlos; et al.; Identification of and molecular basis for SIRT6 loss-of-function point mutations in cancer; Elsevier Inc; Cell Reports; 13; 3; 10-2015; 479-488 | - |
| dc.identifier | 2211-1247 | - |
| dc.identifier | http://hdl.handle.net/11336/13585 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/300225 | - |
| dc.description | Chromatin factors have emerged as the most frequently dysregulated family of proteins in cancer. We have previously identified the histone deacetylase SIRT6 as a key tumor suppressor, yet whether point mutations are selected for in cancer remains unclear. In this manuscript, we characterized naturally occurring patient-derived SIRT6 mutations. Strikingly, all the mutations significantly affected either stability or catalytic activity of SIRT6, indicating that these mutations were selected for in these tumors. Further, the mutant proteins failed to rescue sirt6 knockout (SIRT6 KO) cells, as measured by the levels of histone acetylation at glycolytic genes and their inability to rescue the tumorigenic potential of these cells. Notably, the main activity affected in the mutants was histone deacetylation rather than demyristoylation, pointing to the former as the main tumor-suppressive function for SIRT6. Our results identified cancer-associated point mutations in SIRT6, cementing its function as a tumor suppressor in human cancer. | - |
| dc.description | Fil: Kugel, Sita . Harvard Medical School; Estados Unidos | - |
| dc.description | Fil: Feldman, Jessica L. . University Of Wisconsin; Estados Unidos | - |
| dc.description | Fil: Klein, Mark A.. University Of Wisconsin; Estados Unidos | - |
| dc.description | Fil: Silberman, Dafne Magali. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina | - |
| dc.description | Fil: Sebastián, Carlos. Harvard Medical School; Estados Unidos | - |
| dc.description | Fil: Mermel, Craig. Harvard Medical School; Estados Unidos | - |
| dc.description | Fil: Dobersch, Stephanie . Institute Max Planck for Heart and Lung Research; Alemania | - |
| dc.description | Fil: Clark, Abbe R.. Harvard Medical School; Estados Unidos | - |
| dc.description | Fil: Getz, Gad. Harvard Medical School; Estados Unidos | - |
| dc.description | Fil: Denu, John M.. University Of Wisconsin; Estados Unidos | - |
| dc.description | Fil: Mostoslavsky, Raul. Harvard Medical School; Estados Unidos | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Elsevier Inc | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S2211124715010335 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.celrep.2015.09.022 | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | SIRT6 | - |
| dc.subject | genetic | - |
| dc.subject | cancer | - |
| dc.subject | Bioquímica y Biología Molecular | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Identification of and molecular basis for SIRT6 loss-of-function point mutations in cancer | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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