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dc.creatorMartinez, María Julia-
dc.creatorMartos, Gustavo-
dc.creatorMolina, Elena-
dc.creatorPilosof, Ana Maria Renata-
dc.date2018-09-13T20:23:11Z-
dc.date2018-09-13T20:23:11Z-
dc.date2016-07-
dc.date2018-09-13T13:15:04Z-
dc.date.accessioned2019-04-29T15:43:27Z-
dc.date.available2019-04-29T15:43:27Z-
dc.date.issued2018-09-13T20:23:11Z-
dc.date.issued2018-09-13T20:23:11Z-
dc.date.issued2016-07-
dc.date.issued2018-09-13T13:15:04Z-
dc.identifierMartinez, María Julia; Martos, Gustavo; Molina, Elena; Pilosof, Ana Maria Renata; Reduced β-lactoglobulin IgE binding upon in vitro digestion as a result of the interaction of the protein with casein glycomacropeptide; Elsevier; Food Chemistry; 192; 7-2016; 943-949-
dc.identifier0308-8146-
dc.identifierhttp://hdl.handle.net/11336/59626-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/300364-
dc.descriptionThe aim of this work was to evaluate the effect of the presence of casein glycomacropeptide (CMP) on the in vitro digestibility and potential allergenicity of β-lactoglobulin (β-lg)-CMP mixtures. The digestion products were analyzed by RP-HPLC and RP-HPLC-ESI-MS/MS. The potential allergenicity of the digestion products was studied by human IgE binding by inhibition ELISA with serum samples from children with clinical allergic symptoms to β-lg. No differences were observed by HPLC in the mixtures hydrolysates due to CMP-β-lg interactions. RP-HPLC-ESI-MS/MS results showed different peptides occurring in the mixtures hydrolysates. Additionally, it was observed a significant reduction of β-lg IgE binding in the presence of CMP. The disappearance of epitopes in the digested mixtures could explain the lower IgE binding observed in these systems compared to β-lg. It can be concluded that the presence of CMP in products containing β-lg may modify the digestion products that may reduce the potential allergenicity of β-lg.-
dc.descriptionFil: Martinez, María Julia. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Industrias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Martos, Gustavo. Instituto de Investigación en Ciencias de Alimentación; España. Consejo Superior de Investigaciones Científicas; España. Universidad Autónoma de Madrid; España-
dc.descriptionFil: Molina, Elena. Instituto de Investigación en Ciencias de Alimentación; España. Consejo Superior de Investigaciones Científicas; España. Universidad Autónoma de Madrid; España-
dc.descriptionFil: Pilosof, Ana Maria Renata. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Industrias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherElsevier-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0308814615011309-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.foodchem.2015.07.097-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectALLERGENICITY-
dc.subjectDIGESTION-
dc.subjectINTERACTIONS-
dc.subjectOtras Ciencias Químicas-
dc.subjectCiencias Químicas-
dc.subjectCIENCIAS NATURALES Y EXACTAS-
dc.titleReduced β-lactoglobulin IgE binding upon in vitro digestion as a result of the interaction of the protein with casein glycomacropeptide-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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