Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Uranga, Romina Maria | - |
| dc.creator | Millán, Carola | - |
| dc.creator | Barahona, María José | - |
| dc.creator | Recabal, Antonia | - |
| dc.creator | Salgado, Magdiel | - |
| dc.creator | Martinez, Fernando | - |
| dc.creator | Ordenes, Patricio | - |
| dc.creator | Elizondo Vega, Roberto | - |
| dc.creator | Sepúlveda, Fernando | - |
| dc.creator | Uribe, Elena | - |
| dc.creator | García Robles, María de los Ángeles | - |
| dc.date | 2018-04-05T21:25:53Z | - |
| dc.date | 2018-04-05T21:25:53Z | - |
| dc.date | 2017-06-16 | - |
| dc.date | 2018-04-04T13:13:00Z | - |
| dc.date.accessioned | 2019-04-29T15:43:31Z | - |
| dc.date.available | 2019-04-29T15:43:31Z | - |
| dc.date.issued | 2018-04-05T21:25:53Z | - |
| dc.date.issued | 2018-04-05T21:25:53Z | - |
| dc.date.issued | 2017-06-16 | - |
| dc.date.issued | 2018-04-04T13:13:00Z | - |
| dc.identifier | Uranga, Romina Maria; Millán, Carola; Barahona, María José; Recabal, Antonia; Salgado, Magdiel; et al.; Adenovirus-mediated suppression of hypothalamic glucokinase affects feeding behavior; Nature Publishing Group; Scientific Reports; 7; 1; 16-6-2017; 1-16 | - |
| dc.identifier | 2045-2322 | - |
| dc.identifier | http://hdl.handle.net/11336/41025 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/300389 | - |
| dc.description | Glucokinase (GK), the hexokinase involved in glucosensing in pancreatic β-cells, is also expressed in arcuate nucleus (AN) neurons and hypothalamic tanycytes, the cells that surround the basal third ventricle (3V). Several lines of evidence suggest that tanycytes may be involved in the regulation of energy homeostasis. Tanycytes have extended cell processes that contact the feeding-regulating neurons in the AN, particularly, agouti-related protein (AgRP), neuropeptide Y (NPY), cocaine- and amphetamine-regulated transcript (CART) and proopiomelanocortin (POMC) neurons. In this study, we developed an adenovirus expressing GK shRNA to inhibit GK expression in vivo. When injected into the 3V of rats, this adenovirus preferentially transduced tanycytes. qRT-PCR and Western blot assays confirmed GK mRNA and protein levels were lower in GK knockdown animals compared to the controls. In response to an intracerebroventricular glucose injection, the mRNA levels of anorexigenic POMC and CART and orexigenic AgRP and NPY neuropeptides were altered in GK knockdown animals. Similarly, food intake, meal duration, frequency of eating events and the cumulative eating time were increased, whereas the intervals between meals were decreased in GK knockdown rats, suggesting a decrease in satiety. Thus, GK expression in the ventricular cells appears to play an important role in feeding behavior. | - |
| dc.description | Fil: Uranga, Romina Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad de Concepción; Chile | - |
| dc.description | Fil: Millán, Carola. Universidad de Concepción; Chile. Universidad Adolfo Ibañez; Chile | - |
| dc.description | Fil: Barahona, María José. Universidad de Concepción; Chile | - |
| dc.description | Fil: Recabal, Antonia. Universidad de Concepción; Chile | - |
| dc.description | Fil: Salgado, Magdiel. Universidad de Concepción; Chile | - |
| dc.description | Fil: Martinez, Fernando. Universidad de Concepción; Chile | - |
| dc.description | Fil: Ordenes, Patricio. Universidad de Concepción; Chile | - |
| dc.description | Fil: Elizondo Vega, Roberto. Universidad de Concepción; Chile | - |
| dc.description | Fil: Sepúlveda, Fernando. Universidad de Concepción; Chile | - |
| dc.description | Fil: Uribe, Elena. Universidad de Concepción; Chile | - |
| dc.description | Fil: García Robles, María de los Ángeles. Universidad de Concepción; Chile | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Nature Publishing Group | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/s41598-017-03928-x | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-017-03928-x | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | GLUCOKINASE | - |
| dc.subject | TANYCYTES | - |
| dc.subject | HIPOTHALAMUS | - |
| dc.subject | FEEDING BEHAVIOR | - |
| dc.subject | Otras Ciencias Biológicas | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Adenovirus-mediated suppression of hypothalamic glucokinase affects feeding behavior | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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