Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | González Iglesias, Arturo | - |
| dc.creator | Suarez, Cecilia | - |
| dc.creator | Feierstein, Claudia | - |
| dc.creator | Diaz, Graciela Susana | - |
| dc.creator | Becu, Damasia | - |
| dc.date | 2017-12-21T13:55:19Z | - |
| dc.date | 2017-12-21T13:55:19Z | - |
| dc.date | 2001-12 | - |
| dc.date | 2017-12-04T17:54:24Z | - |
| dc.date.accessioned | 2019-04-29T15:44:02Z | - |
| dc.date.available | 2019-04-29T15:44:02Z | - |
| dc.date.issued | 2017-12-21T13:55:19Z | - |
| dc.date.issued | 2017-12-21T13:55:19Z | - |
| dc.date.issued | 2001-12 | - |
| dc.date.issued | 2017-12-04T17:54:24Z | - |
| dc.identifier | Becu, Damasia; Diaz, Graciela Susana; Feierstein, Claudia; Suarez, Cecilia; González Iglesias, Arturo; Desensitization of Angiotensin II effect on [Ca2+]i, inositol triphosphate and prolactin in pituitary cells; American Physiological Society; American Journal Of Physiology-endocrinology And Metabolism; 280; 3; 12-2001; 462-470 | - |
| dc.identifier | 0193-1849 | - |
| dc.identifier | http://hdl.handle.net/11336/31195 | - |
| dc.identifier | 1522-1555 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/300616 | - |
| dc.description | Activation of pituitary angiotensin (ANG II) type 1 receptors (AT1) mobilizes intracellular Ca2+, resulting in increased prolactin secretion. We first assessed desensitization of AT1 receptors by testing ANG II-induced intracellular Ca2+ concentration ([Ca2+](i)) response in rat anterior pituitary cells. A period as short as 1 min with 10(-7) M ANG II was effective in producing desensitization (remaining response was 66.8 +/- 2.1% of nondesensitized cells). Desensitization was a concentration-related event (EC(50): 1.1 nM). Although partial recovery was obtained 15 min after removal of ANG II, full response could not be achieved even after 4 h (77.6 +/- 2.4%). Experiments with 5 x 10(-7) M ionomycin indicated that intracellular Ca2+ stores of desensitized cells had already recovered when desensitization was still significant. The thyrotropin-releasing hormone (TRH)-induced intracellular Ca2+ peak was attenuated in the ANG II-pretreated group. ANG II pretreatment also desensitized ANG II- and TRH-induced inositol phosphate generation (72.8 +/- 3.5 and 69.6 +/- 6.1%, respectively, for inositol triphosphate) and prolactin secretion (53.4 +/- 2.3 and 65.1 +/- 7.2%), effects independent of PKC activation. We conclude that, in pituitary cells, inositol triphosphate formation, [Ca2+](i) mobilization, and prolactin release in response to ANG II undergo rapid, long-lasting, homologous and heterologous desensitization. | - |
| dc.description | Fil: González Iglesias, Arturo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina | - |
| dc.description | Fil: Suarez, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina | - |
| dc.description | Fil: Feierstein, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina | - |
| dc.description | Fil: Diaz, Graciela Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina | - |
| dc.description | Fil: Becu, Damasia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | American Physiological Society | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.physiology.org/doi/full/10.1152/ajpendo.2001.280.3.E462 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1152/ajpendo.2001.280.3.E46 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/?term=11171601%5Buid%5D | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | ENDOCRINOLOGY | - |
| dc.subject | PITUITARY GLAND | - |
| dc.subject | ANGIOTENSIN II | - |
| dc.subject | PROLACTIN | - |
| dc.subject | PROTEIN KINASE | - |
| dc.subject | Inmunología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.subject | Bioquímica y Biología Molecular | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Desensitization of Angiotensin II effect on [Ca2+]i, inositol triphosphate and prolactin in pituitary cells | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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