Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Toni, Nicolas | - |
| dc.creator | Laplagne, Diego Andres | - |
| dc.creator | Zhao, Chunmei | - |
| dc.creator | Lombardi, María Gabriela | - |
| dc.creator | Ribak, Charles E. | - |
| dc.creator | Gage, Fred H. | - |
| dc.creator | Schinder, Alejandro Fabián | - |
| dc.date | 2018-04-19T18:22:57Z | - |
| dc.date | 2018-04-19T18:22:57Z | - |
| dc.date | 2008 | - |
| dc.date | 2018-04-05T19:24:12Z | - |
| dc.date.accessioned | 2019-04-29T15:44:03Z | - |
| dc.date.available | 2019-04-29T15:44:03Z | - |
| dc.date.issued | 2018-04-19T18:22:57Z | - |
| dc.date.issued | 2018-04-19T18:22:57Z | - |
| dc.date.issued | 2008 | - |
| dc.date.issued | 2018-04-05T19:24:12Z | - |
| dc.identifier | Toni, Nicolas; Laplagne, Diego Andres; Zhao, Chunmei; Lombardi, María Gabriela; Ribak, Charles E.; et al.; Neurons born in the adult dentate gyrus form functional synapses with target cells; Nature Publishing Group; Nature Neuroscience.; 11; 8; 2008; 901-907 | - |
| dc.identifier | 1097-6256 | - |
| dc.identifier | http://hdl.handle.net/11336/42708 | - |
| dc.identifier | 1546-1726 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/300621 | - |
| dc.description | Adult neurogenesis occurs in the hippocampus and the olfactory bulb of the mammalian CNS. Recent studies have demonstrated that newborn granule cells of the adult hippocampus are postsynaptic targets of excitatory and inhibitory neurons, but evidence of synapse formation by the axons of these cells is still lacking. By combining retroviral expression of green fluorescent protein in adult-born neurons of the mouse dentate gyrus with immuno-electron microscopy, we found output synapses that were formed by labeled terminals on appropriate target cells in the CA3 area and the hilus. Furthermore, retroviral expression of channelrhodopsin-2 allowed us to light-stimulate newborn granule cells and identify postsynaptic target neurons by whole-cell recordings in acute slices. Our structural and functional evidence indicates that axons of adult-born granule cells establish synapses with hilar interneurons, mossy cells and CA3 pyramidal cells and release glutamate as their main neurotransmitter. | - |
| dc.description | Fil: Toni, Nicolas. Salk Institute for Biological Studies; Estados Unidos | - |
| dc.description | Fil: Laplagne, Diego Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina | - |
| dc.description | Fil: Zhao, Chunmei. Salk Institute for Biological Studies; Estados Unidos | - |
| dc.description | Fil: Lombardi, María Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina | - |
| dc.description | Fil: Ribak, Charles E.. University of California at Irvine; Estados Unidos | - |
| dc.description | Fil: Gage, Fred H.. Salk Institute for Biological Studies; Estados Unidos | - |
| dc.description | Fil: Schinder, Alejandro Fabián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Nature Publishing Group | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/nn.2156 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/nn.2156 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | Action Potentials/drug effects | - |
| dc.subject | Action Potentials/physiology | - |
| dc.subject | Action Potentials/radiation effects | - |
| dc.subject | Animals | - |
| dc.title | Neurons born in the adult dentate gyrus form functional synapses with target cells | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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